In this work, we examined enhanced skin delivery of minoxidil applied in nanoemulsions incorporating skin penetration enhancers. Aliquots of fully characterized oil-in-water nanoemulsions (1 mL), containing minoxidil (2%) and the skin penetration enhancer oleic acid or eucalyptol as oil phases, were applied to full-thickness excised human skin in Franz diffusion cells, while aqueous solutions (...

Cationic lipids have been used in the development of non-viral gene delivery systems as lipoplexes. Stearylamine, a cationic lipid that presents a primary amine group when in solution, is able to compact genetic material by electrostatic interactions. In dispersed systems such as nanoemulsions this lipid anchors on the oil/water interface confering a positive charge to them. The aim of this wor...

Background: Mobile phones, use electromagnetic radiation in the microwave range. On the other hand, there is only one report on radioprotective effects of flaxseed oil. The aim of this study was to investigate the effect of irradiation of rats with microwaves and/or treatment with flaxseed oil on the induction of adaptive response to a subsequent lethal dose (LD) of gamma rays. Materia...

Background Flax is a plant that is widely cultivated and has multiple uses. The seed has been increasingly used in food, and the fibers are used in textiles. Oils have also been extracted from the seed for use as a laxative and in industrial preparations. Allergic reactions to flax seed ingestion as well as linseed oil (flaxseed oil) ingestion have been described in the literature in adults (1-...

Flaxseed has been known since the Stone Ages. Originating in Mesopotamia, it has long history of use in India and was a commonly used food before World War II. Flaxseed cultivation and popularity declined aft er the fall of Rome and gradually forgotten until 1990s. Flaxseed oil, lignan precursors and its mucilage have many potential uses in the prevention or treatment of disease as a nutraceuti...

Flaxseed oil is known as a functional oil because of the high content of α-linolenic acid; therefore, the aim of this research was to investigate some physicochemical properties of Iranian extra virgin flaxseed oil (EVFO) and the impact of the refining stages before deodorization on these properties. Fatty acid composition, peroxide and anisidine values, free fatty acids, Crystallization point,...

The integration of therapeutic and imaging functions in a nanoscale structure is gaining increasing attention to monitor drug and gene delivery in a non-invasive real-time manner. Here we introduce radioopaque nanoemulsions incorporating paclitaxel and Bcl-2 small interfering RNA (siRNA) for synergistic anti-cancer theranostics. Water-insoluble paclitaxel is readily dissolved in iodinated poppy...

BACKGROUND Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate thei...

Nanotechnology, shortened to nanotech, is the study of the controlling of matter on an atomic and molecular scale. Generally, nanotechnology deals with structures sized between 1 to 100 nanometer in at least one dimension and involves developing materials or devices within that size. The use of nanotechnology in the field of pharmaceutics and drug delivery has grown over the last few years, so ...

Flaxseed is a rich source of different types of phenolics such as lignans, phenolic acids, flavonoids, phenylpropanoids and tannins. To date, extensive investigations has been undertaken to demonstrate antioxidant potential of flaxseed phenolics. However, antioxidant potential of all the flaxseed phenolics has not been collectively discussed. Hence, the aim of this article is to highlight the v...