Cryogen spray cooling (CSC) has been used for selective epidermal cooling of human skin during laser therapy of patients with port wine stain (PWS) birthmarks. Unfortunately, current commercial CSC devices do not provide optimal cooling selectivity and, therefore, provide insufficient epidermal protection for some PWS patients. To assist in the development of improved atomizing nozzle designs, ...

OBJECTIVE To compare the clinical response of keloidal and hypertrophic scars after treatment with intralesional corticosteroid alone or combined with 5-fluorouracil (5-FU), 5-FU alone, and the 585-nm flashlamp-pumped pulsed-dye laser (PDL). DESIGN Prospective, paired-comparison, randomized controlled trial. SETTING A private ambulatory laser facility. PATIENTS Ten patients with previousl...

For most experimental applications where organic dye lasers are used as light sources, it is necessary to narrow the spectral output which is up to a few hundred Ängstroms wide. Spectral narrowing down to 0.5 — 1 Ä can be achieved by using a diffraction grating as one of the resonator mirrors a set of prisms2 or an interference filter inside the laser cavity3. Further reduction of the emission ...

Based on the assumption that the maximum irradiance allowed during laser treatment of port wine stains is limited by the temperature rise at the dermoepidermal junction, we theoretically investigated how much the irradiance could be increased by dynamically cooling the skin surface. The heat condution equation was solved numerically in cylindrical coordinates using a skin model composed of four...

Rapid concentration jumps of Ins(1,4,5)P3 or ATP were made inside Limulus ventral photoreceptors by flash photolysis of the parent caged compounds. In intact ventral photoreceptors, the photolysis flash evokes a maximum amplitude light-activated current; therefore, a procedure was developed for uncoupling phototransduction by blocking two of the initial reactions in the cascade, rhodopsin excit...

P0005 Particular care must be used when characterizing the excitation beam in nonlinear optical experiments compared to linear measurements. By definition, nonlinear optical phenomena depend on the electric field to high order. The higher the order, the more sensitive the observed behavior depends on the input. Extracting a representative nonlinear coefficient from an experiment, for example, b...

These experiments employ the photoisomerizable compound, 3,3'bis-[a-(trimethylammonium)methyl]azobenzene (Bis-Q), to study the response to muscarinic agents in frog myocardium . In homogenates from the heart, transBis-Q blocks the binding of [3H]-N-methylscopolamine to muscarinic receptors . In voltage-clamped atrial trabeculae, trans-Bis-Q blocks the agonist-induced potassium conductance. The ...

1. Experiments were performed on hippocampal CA1 pyramidal cells to investigate the time course of a slow, Ca(2+)-activated K+ current that follows a burst of action potentials. At a temperature of 27-30 degrees C, this current rises to a peak 200-400 ms following the cessation of Ca2+ entry before decaying to baseline in 4-8s. 2. Intracellular recordings were made using electrodes containing t...

Intense Pulsed Light (IPL) is a broadband visible light emitted from a non-coherent, filtered flashlamp. IPL sources emit light in the 500-1200 nm range and allow treatment of vascular and melanocytic lesions, and also hair removal. Different cutoff filters can be used to narrow the spectrum to target specific structures. 1 We report significant changes observed in two nevi after hair removal t...