Urinary tract infections (UTIs) are one of main health problems caused by many microorganisms, including uropathogenic Escherichia coli (UPEC). The virulence factors important in colonization UPEC, extra-intestinal survival, and creation cytopathic effects. In addition, the expression special UPEC can contribute to uropathogenicity, as well worsening UTIs. this study, 134 isolates E. were colle...

Urinary tract infections (UTI) caused primarily by uropathogenic Escherichia coli (UPEC) are indeed an extremely contagious disease that affects people all over the world. FimH is a major virulence component in UTI pathogenesis, and inhibiting function can be efficient means to disarm UPEC bacteria, as well crucial target development of non-antibiotic mediated treatment options. The goal this s...

has been approved by the Examining Committee for the thesis requirement for the Master of Science degree in Microbiology at the May 2012 graduation. ii ACKNOWLEDGEMENTS I would like to thank Dr. Steve Clegg for his support and guidance during my time in his lab. He has helped me learn a lot about how to do science and how to think about science. He has been supportive of the decisions I have ma...

UNLABELLED The first step in the infection of humans by microbial pathogens is their adherence to host tissue cells, which is frequently based on the binding of carbohydrate-binding proteins (lectin-like adhesins) to human cell receptors that expose glycans. In only a few cases have the human receptors of pathogenic adhesins been described. A novel strategy-based on the construction of a lectin...

Problem statement: Omphalitis is one of the most common causes of mortality in chicks during the first week after hatching. Escherichia coli strains are the most common isolated bacteria from omphalitis cases of chickens. Bacterial colonization in the host cells surfaces is a critical first step in the pathogenesis of avian pathogenic Escherichia coli isolates. Thus the current study was undert...