OBJECTIVE To assess the long-term impact of standard lobectomy on respiratory function in octogenarian patients with mild/moderate chronic obstructive pulmonary disease (COPD). METHODS We reviewed all octogenarians (n=38), who underwent lobectomy for stage I-II non-small-cell lung cancer (NSCLC) from 2000 to 2006. Inclusion criteria were: Tiffenau index<0.7, no adjuvant therapies, smoking ces...

TOPIC: Obstructive Lung Diseases TYPE: Original Investigations PURPOSE: Due to the difficulty of forced vital capacity (FVC) maneuver, Forced expiratory volume in one second (FEV1)/Forced six seconds (FEV6); (FEV1/FEV6) has been proposed as alternative value for obstructive lung detection. We aim compare sensitivity and specificity FEV1/FEV6 among different gender race. METHODS: Retrospective d...

OBJECTIVE To investigate the presence of airway obstruction by determining the FEV1/FVC and FEV1/slow vital capacity (SVC) ratios. METHODS This was a quantitative, retrospective cross-sectional study. The sample comprised 1,084 individuals who underwent spirometry and plethysmography in a central hospital in Lisbon, Portugal. The study sample was stratified into six groups, by pulmonary funct...

BACKGROUND Chronic obstructive pulmonary diseases (COPD) have been defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) as irreversible conditions which are diagnosed by fixed cut-off points of FEV1/FVC. OBJECTIVE The aim of this study was to determine the cut-off points for FEV1/FEV6 ratio and FEV6 as alternatives for FEV1/FVC and FVC in detection of airway obstructio...

introduction: renal failure affects the mechanical and the ventilatory function of the lungs. a few studies have evaluated the ventilatory and pulmonary function in dialysis patients. the present study aimed to compare pulmonary function test (pft) results in patients undergoing hemodialysis (hd) and peritoneal dialysis (pd). materials and methods: we conducted a cross-sectional study on 50  pa...

Since 1991, the guidelines for interpretation of lung function tests endorsed by the American Thoracic Society (ATS) have recommended that the presence of airflow obstruction be determined by a reduction in the ratio of FEV1 to FVC (or vital capacity), but that the severity of the obstructive impairment be indicated by the reduction in FEV1 itself, expressed as a percent of its predicted value ...

To define bronchoreversibility they unfortunately followed the American Thoracic Society/European Respiratory Society (ATS/ERS) guideline recommendations for FEV1 responses [2]. These guidelines require both a 12% increase in FEV1 and a 200-mL increase in FEV1 to indicate a positive test, levels which are based on expert opinions rather than statistical analysis of individual patients. Conseque...

Background: Individuals with severely impaired lung function have an increased risk of lung cancer. Whether milder reductions in forced expiratory volume in 1 second (FEV1) also increase the risk of lung cancer is controversial. Moreover, there is little consensus on whether men and women have similar risks for lung cancer for similar decreases in FEV1. Methods: A search was conducted of PubMed...

BACKGROUND MicroRNAs are key transcriptional and network regulators previously associated with asthma susceptibility. However, their role in relation to asthma severity has not been delineated. OBJECTIVE We hypothesized that circulating microRNAs could serve as biomarkers of changes in lung function in asthma patients. METHODS We isolated microRNAs from serum samples obtained at randomizati...