BACKGROUND Adults with sickle cell anemia (HbSS) are inconsistently treated with hydroxyurea. OBJECTIVES We retrospectively evaluated the effects of elevating fetal hemoglobin with hydroxyurea on organ damage and survival in patients enrolled in our screening study between 2001 and 2010. METHODS An electronic medical record facilitated development of a database for comparison of study param...

Cell proliferation kinetics during growth of an estrogen recep tor-positive human breast carcinoma cell line, T-47D, was de fined, and some factors which modify its response to tamoxifen were investigated in vitro. T-47D cells were estrogen responsive when grown in charcoal-stripped fetal calf serum, but the addition of 17/3-estradiol did not fully restore the growth rate to that observed in th...

Cell proliferation kinetics during growth of an estrogen receptor-positive human breast carcinoma cell line, T-47D, was defined, and some factors which modify its response to tamoxifen were investigated in vitro. T-47D cells were estrogen responsive when grown in charcoal-stripped fetal calf serum, but the addition of 17 beta-estradiol did not fully restore the growth rate to that observed in t...

Exposure to di (n-butyl) phthalate (DBP) in utero impairs the development of the male rat reproductive tract. The adverse effects are due in part to a coordinated decrease in expression of genes involved in cholesterol transport and steroidogenesis with a resultant reduction in testosterone production in the fetal testis. To determine the dose-response relationship for the effect of DBP on ster...

Prenatal exposure to TCDD interferes with fetal development at doses lower than those causing overt toxicity in adult animals. Exposure to TCDD during development produces alterations in the reproductive system of the developing pups- delayed puberty and reduced sperm counts in males and malformations in the external genitalia of females. The objectives of this study were to determine maternal ...

The potential maternal, embryotoxic, and teratogenic parameters of 2,4-dichlorophenol (2,4-DCP) were evaluated in Fischer 344 rats following oral administration in corn oil on Days 6 through 15 of gestation. Dose levels were 0, 200, 375, and 750 mg/kg/day. Females were sacrificed on Gestation Day 20 and cesarean sections performed. The fetuses were weighed, sexed, measured for crown-rump length...