In this attempt to forge a useful algorithm for the management of iron deficiency, it is prudent to have a discussion of the difference between overt iron deficiency, where the body iron stores are depleted, and functional iron deficiency, also known as iron restricted erythropoiesis, where ample iron is present, but unavailable. Prior to the discovery of hepcidin, the hepatic synthesized iron ...

A sequence within the E2 domain of soluble amyloid precursor protein (sAPP) stimulates iron efflux. This activity has been attributed to a ferroxidase activity suggested for this motif. We demonstrate that the stimulation of efflux supported by this peptide and by sAPPα is due to their stabilization of the ferrous iron exporter, ferroportin (Fpn), in the plasma membrane of human brain microvasc...

The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells. Hepcidin insufficiency causes hyperabsorption of dietary iron, hyperferremia and tissue iron overload, which are hallmarks of hereditary hemochromatosis. Similar responses are also observed in iron-loading anemias due to ineffective erythropoiesis...

826 haematologica/journal of hematology vol. 88(07):july 2003 common mutation in hemochromastosis type 4. Blood 2002;100:733-4. 8. Camaschella C, Roetto A, De Gobbi M. Genetic haemochromatosis: genes and mutations associated with iron loading Best Pract Res Clin Haematol 2002;15:261-76. 9. Cazzola M, Cremonesi L, Papaioannou M, Soriani N, Kioumi A, Charalambidou A, et al. Genetic hyperferritina...

Iron is an essential metallic microelement for life. However, iron overload is toxic. The liver serves an important role as a storehouse for iron in the body. About 20-25 mg of iron is required each day for hemoglobin synthesis. To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved in the uptake of iron into hepatocytes, ferritin in its storage, and ferropor...