background selenium deficiency is a common problem in patients with chronic kidney disease (ckd). this micronutrient has anti-inflammatory and anti-oxidant effects. selenium is also found in high concentrations in the thyroid gland. objectives to determine the effect of selenium supplementation on thyroid function tests and acute phase reactants in hemodialysis patients. patients and methods in...

Emergence of tuberculosis as a global health threat has necessitated an urgent search for new antitubercular drugs entailing determination of 3-dimensional structures of a large number of mycobacterial proteins for structure-based drug design. The essential requirement of ferritins/bacterioferritins (proteins involved in iron storage and homeostasis) for the survival of several prokaryotic path...

The protein shells of rat tissue ferritins consist of two subunit species (heavy (H) and light (L)) in proportions varying according to the tissue and its iron content. Rat liver and heart ferritins were resolved by electrofocusing into a series of charge isomers that change progressively in H:L subunit ratios along the PI gradient, suggesting that net surface charge is determined by the subuni...

Since the bullfrog H-ferritin L134P mutant in which leucine 134 is replaced with proline was found to exhibit a flexible conformation C3 axis channel, homologous ferritins corresponding mutation have often been studied terms of mechanism iron release from mineral core within protein cavity. Meanwhile, ferritin channel an attractive material developing method encapsulate functional molecules lar...

Mammalian ferritins are iron-storage proteins made of 24 subunits of two types: the H- and L-chains. L-chains, in contrast with H-chains, lack detectable ferroxidase activity. When ferritins were subjected to iron loading in vitro with increments near the saturation limit of 4000 Fe atoms per molecule, the homopolymers of human H-chains formed insoluble aggregates, caused by non-specific iron h...