Topology optimization is presently used in most diverse scientific, technologic and industrial areas, including biomechanics. Bone remodelling models and structural optimization has mutually provided inspiration for new developments in biomechanics and biomedicine. Considering that bone has the ability to adapt its internal structure to mechanical loading (Wolff’s law and Roux’s paradigm), it i...

Progressive loss of bone mineral density around the femora! component of total hip replacement continues to pose a threat to long term prosthetic survival. A linear study was undertaken to measure bone mineral density on a monthly basis following total hip arthroplasty in 11 male patients. The opposite femur was used as the control measurement. Bone mineral density was unchanged at two mo...

A laser ablation ICP-MS technique has been used to examine the radial distribution of lead in transverse sections of alligator femur. Annual bone growth in the femur results in the deposition of incremental layers of calcified tissue at the periphery of existing bone. Patterns of lead concentration within these layers provide a record of time-dependent accumulation from which exposure history c...

INTRODUCTION We investigated the association between bone mineral density (BMD) detected by dual-energy X-ray absorptiometric (DXA) method and blood pressure (BP) in a large sample of postmenopausal women. MATERIAL AND METHODS The current study was based on a retrospective analysis of 586 postmenopausal women with a mean age of 60.8 ±8.8 years, who were screened for osteopenia or osteoporosis...

BACKGROUND Ethnic dimorphism in the distal femur has never been studied in a three-dimensional analysis focused on shape instead of size. Yet, this dimorphism has direct implications in orthopedic surgery and in anthropology. The goal of this study was to show that differences in distal femur shape related to ethnic dimorphism could be identified, visualized, and quantified using 3D geometric m...

INTRODUCTION In the normal hip, stress is distributed over the entire crossection of the femur. Bending and axial compression are the major modes of loading. Following THA, the stress in the bone is significantly different mainly due to the manner in which the load is transferred to the femur (Huiskes, 1990, Huiskes, 1995). In this case, the load is primarily transferred through shear across th...

Clark, Paul A., Anthony Rodriguez, D. Rick Sumner, Mohammad A. Hussain, and Jeremy J. Mao. Modulation of bone ingrowth of rabbit femur titanium implants by in vivo axial micromechanical loading. J Appl Physiol 98: 1922–1929, 2005. First published January 7, 2005; doi:10.1152/japplphysiol.01080.2004.—Titanium implants commonly used in orthopedics and dentistry integrate into host bone by a compl...

OBJECTIVE The aim of this study was to assess bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) in a group of patients with ankylosing spondylitis (AS) and the factors which have an impact on bone mass. Also, a subgroup of patients not treated with anti-osteoporotic or disease-modifying anti-rheumatic drugs was followed for 24 months to assess potential influencing factors...

One of the most important but least studied environmental factors playing a major role in bone physiology is gravity. While the knowledge of deleterious effects of microgravity on the skeleton is expanding, little is known about hypergravity and its osteogenic potential. Centrifugation was used to assess effects of 21-day continuous 2- or 3-g acceleration on femur and L2-vertebra of 7-wk-old ma...

Bone metastasis alone without involvement of bone marrow is rarely seen in primary breast lymphoma (PBL). It has a poor prognosis. A 64-years old woman was diagnosed as high-grade PBL T type. The patient received 6 sessions of chemotherapy with a diagnosis of stage IIAE PBL. The patient achieved remission and was followed for 12 years. She underwent surgery due to fracture at lower half of righ...