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Capsule endoscopy (CE) is a safe, non invasive diagnostic modality for the evaluation of small bowel lesions. Obscure gastrointestinal bleeding (OGIB) is one of the most important indications of capsule endoscopy. Capsule endoscopy has a very high diagnostic yield especially if the bleeding is ongoing. This technique appears to be superior to other techniques for the detection of suspected lesi...

BACKGROUND This open-label, crossover study examined lisdexamfetamine dimesylate (LDX) and D-amphetamine pharmacokinetics in healthy adults after administration of an intact LDX capsule or after the capsule was emptied into orange juice or yogurt and the contents consumed. METHODS Healthy adult volunteers (N = 30) were administered a 70-mg LDX capsule or the contents of a 70-mg capsule mixed ...

Small-bowel video capsule endoscopy (VCE) is generally contraindicated in patients with swallowing disorders. However, it is difficult to judge the ability of patients to swallow a capsule endoscope before examination and accidental aspiration of capsule endoscopes has been reported [1–3]. Previously, it was reported that overtube-assisted VCE placement was useful [4,5]. A 64-year-old man under...

Cryptococcus neoformans is an opportunistic fungal pathogen that causes serious human disease in immunocompromised populations. Its polysaccharide capsule is a key virulence factor which is regulated in response to growth conditions, becoming enlarged in the context of infection. We used microarray analysis of cells stimulated to form capsule over a range of growth conditions to identify a tran...

BACKGROUND AND AIMS There are contradictory findings regarding long-term outcome in patients with obscure gastrointestinal bleeding and negative capsule endoscopy. Factors associated with rebleeding after a negative videocapsule are not entirely known. OBJECTIVE The aim of this study was to compare the rebleeding rate between negative and positive capsule endoscopy patients and to identify pr...

CONTEXT One of the limitations of 13C-urea breath test for Helicobacter pylori infection diagnosis in Brazil is the substrate acquisition in capsule presentation. OBJECTIVES The purpose of this study was to evaluate a capsule-based 13C-urea, manipulated by the Pharmacy Division, for the clinical practice. METHODS Fifty patients underwent the conventional and the capsule breath test. Samples...

BACKGROUND AND STUDY AIMS  Small bowel cancer is rare, accounting for < 5 % of all gastrointestinal neoplasms. Capsule endoscopy has become the procedure of choice for non-invasive diagnosis of small bowel diseases. Data on capsule endoscopy diagnosis of small bowel cancer are limited. The objective of the study was to determine the frequency, indications and diagnostic work-up of patients with...

Wireless capsule endoscopic devices are adopted for painless diagnosis of cancer and other diseases affecting the gastrointestinal tract as an alternative to traditional endoscopy. Although much work has been done to improve capsule performance in terms of active navigation, a major drawback is the limited available energy on board the capsule, usually provided by a battery. Another key shortco...

A two-dimensional thin-walled capsule of a flexible semi-permeable membrane is adhered onto a rigid planar substrate under adhesive forces (derived from a potential function) in the presence of osmosis across the membrane. The capsule is immersed in a hypotonic and diluted binary solution of a non-electrolyte solute. The Stokes flow problem is solved by the immersed interface method (IIM) with ...