Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common polymorphism and enzymopathy in humans, affecting approximately 400 million people worldwide. It is responsible for various clinical manifestations, including favism, hemolytic anemia, chronic non-spherocytic hemolytic anemia, spontaneous abortion, and neonatal hyperbilirubinemia. Understanding the molecular mechanisms under...

Description Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is the most common human enzyme deficiency that mainly affects the red blood cells (RBCs). A defect in G6PD enzyme leads to the destruction of premature RBCs causing hemolytic anemia because the body can not compensate the destroyed RBCs. Thus, the affected individuals show jaundice (paleness, yellowing of the skin and whites of th...

As many as one-third of mutations in a gene result in the corresponding enzyme having an increased Michaelis constant, or K(m), (decreased binding affinity) for a coenzyme, resulting in a lower rate of reaction. About 50 human genetic dis-eases due to defective enzymes can be remedied or ameliorated by the administration of high doses of the vitamin component of the corresponding coenzyme, whic...

I am very sad to report the passing away of Professor Ugo E.F. Carcassi, a great man, internist, rheumatologist, and co-founder of the European integration of medical sciences. He passed away in his home city, Cagliari, on the 16th of May, 2016. Professor Ugo Efisio Francesco Carcassi was Sardinian; he was born in Cagliari on the 21st of August 1921. He was admitted to the Medical Faculty at th...

ferropenia and consequent iron deficiency anemia (ida), β-thalassemia, and glucose 6-phosphate dehydrogenase (g6pd) deficiency are three main common hematological problems in iran. this study was conducted to investigate the prevalence of these problems in turkish migrating nomads in southern iran. from june to october 2006, the blood sample of 152 turkish migrating nomadic children including 7...

glucose-6-phosphate dehydrogenase (g6pd) enzyme catalyses the first step in pentose phosphate pathway (conversion of glucose-6-phosphat to 6-phospho gluconat) which provides cells with pentoses and reduction power in the form of nadph. in the present study we have analyzed the g6pd gene mutations in 76 patients with a history of favism in khorasan province in iran. dna samples were analyzed for...