We investigated peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands effect on cell motility and the plasminogen activator system using normal MCF-10A and malignant MCF-10CA1 cell lines. Ciglitazone reduced both wound-induced migration and chemotaxis. However, the effect was not reversed with pretreatment of cells with the PPAR-γ-specific antagonist GW9662. Immunoblot analysis of condi...

ABSTRACT: Olives belong to the family of olea europaea L. is a popular fruit tree. The fruit and the oil extracted from it is consumed worldwide particularly in the Mediterranean regions. In this study changes in the fatty acid composition of the oil extracted from olive fruit during the course of maturation is investigated. This work is concerned with the best harvesting point when oleic acid ...

background: to assess the effect of supplementation with vitamins a, e and c and ω-3 fatty acids on lipid peroxidation in strepto zotocin (stz) induced diabetic rats. methods: sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, dia betic with vitamin a, e as well as c supplementation and diabetic with ω-3 fatty acids supplementation. aft...

diet as a part of lifestyle plays a pivotal role in the development of metabolic syndrome and its consequences. fatty acid composition as a part of dietary intake affects blood fatty acid concentrations, insulin sensitivity and different metabolic pathways associated with the occurrence and consequences of the metabolic syndrome. the aim of this review is to evaluate the effects of dietary fatt...

ABSTRACT: Iran is considered number one producer of pomegranate throughout the world. The oil extracted from pomegranate seed is considered to have great medical and nutritional values, therefore the study is concerned with this unique and valuable oil specially its chemical attributes. Five different varieties of pomegranate were obtained from Saveh Pomegranate Research Institute. The seeds we...

in this study, seasonal variations of fatty acid amounts in muscle tissues of capoeta caelestis were investigated. we have found that the ω3 contents of c. caelestis in spring, summer, autumn and winter were 17.43%, 15.29%, 17.54%, 13.63% in female and 16.96%, 19.25%, 18.66%, 14.76% in male, respectively. the amounts of ω3 polyunsaturated fatty acids were higher than those of ω6 polyunsaturated...

Malonyl-CoA functions as a mediator in the hypothalamic sensing of energy balance and regulates the neural physiology that governs feeding behavior and energy expenditure. The central administration of C75, a potent inhibitor of the fatty acid synthase (FAS), increases malonyl-CoA concentration in the hypothalamus and suppresses food intake while activating fatty acid oxidation in skeletal musc...

BACKGROUND Activation of the vascular endothelium by dietary fatty acids may be among the most critical early events in the development of atherosclerosis. However, the specific effects of fatty acids on inflammatory responses in endothelial cells are not fully understood. OBJECTIVE The present study focused on the induction of inflammatory genes in human endothelial cells exposed to individu...

We have studied the substrate specificities of a non-specific activator protein on the enzymatic hydrolyses of the following compounds: GM1 and GM2, as well as several of their derivatives including oligosaccharides, GgOse3Cer-II3-sulfate and LacCer-II3-sulfate, Gb-Ose3Cer and GbOse4Cer, three neolacto-series glycosphingolipids, and two non-ceramide glycolipids. Our results show that this activ...