BACKGROUND Unexplained Chronic Fatigue is a medical condition characterized by the presence of persistent, severe and debilitating medically unexplained fatigue, leading to impaired functioning and lower quality of life. Research suggests that physical activity can contribute to the reduction of fatigue and other somatic symptoms and can thus significantly improve physical functioning and quali...

................................................................................................................... 99 Introduction ............................................................................................................ 100 Method ................................................................................................................... 104 Participants ...............

the fruit of cassia fistula linn. is a legume, has antioxidant and lots of other medicinal properties. as oxidants are involved in the pathogenesis of chronic fatigue syndrome, the present study was done to evaluate the effect of ethanolic extract of fruit pulp of c. fistula linn. (eecf) on forced swimming induced chronic fatigue syndrome (cfs). albino mice of 25-40 grams were grouped into five...

INTRODUCTION Fatigue is prevalent in primary Sjögren's syndrome (pSS), and contributes to the considerably reduced health related quality of life in this disease. The symptom is included in proposed disease activity and outcome measures for pSS. Several studies indicate that there is an inflammatory component of fatigue in pSS and other chronic inflammatory rheumatic diseases. The purpose of th...

Chronic fatigue syndrome is a debilitating illness of unknown aetiology, with estimated levels of prevalence of up to about 8. 7/100 000 in the U.S.A. Like pain fatigue it is a personal, emotionally rich experience, which may originate from peripheral or central sites (or both). The nature of the symptoms is complex and reflects the interaction of the patient with the environment and cultural m...

Fatigue is a common symptom in the community and the commonest associations are with stress or mood disturbance. One in a hundred people complain of unexplained and prolonged fatigue, with half that number meeting the strictest criteria for the chronic fatigue syndrome (CFS). Discrete fatigue syndromes have been described, particularly after Epstein Barr virus infection. The majority of patient...

BACKGROUND Postcancer fatigue is a frequently occurring problem, impairing quality of life. Until now, little is known about (neuro) physiological factors determining postcancer fatigue. For non-cancer patients with chronic fatigue syndrome, certain characteristics of brain morphology and metabolism have been identified in previous studies. We investigated whether these volumetric and metabolic...

BACKGROUND The genesis of severe fatigue and disability in people following acute pathogen invasion involves the activation of Toll-like receptors followed by the upregulation of proinflammatory cytokines and the activation of microglia and astrocytes. Many patients suffering from neuroinflammatory and autoimmune diseases, such as multiple sclerosis, Parkinson's disease and systemic lupus eryth...

p. 68-69. Fletcher, M.A., Maher, K.J. & Klimas, N.G. 2002. Natural killer cell function in chronic fatigue syndrome. Clinic. & Appl. Immunol. Rev., 2, 129-139. Fletcher, M.A., Zeng, X.R., Barnes, Z., Levis, S. & Klimas, N.G. 2009. Plasma cytokines in women with chronic fatigue syndrome. Jl. Transl. Med., 7:96 doi:10.1186/1479-5876-7-96 Flett, G.L., Besser, A., Hewitt, P.L. & Davis, R.A. 2007. P...

1. Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, et al. Identifi cation of a novel gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog. 2006;2:e25. DOI: 10.1371/journal. ppat.0020025 2. Lombardi VC, Ruscetti FW, Das GJ, Pfost MA, Hagen KS, Peterson DL, et al. Detection of an infectious retrovirus, XMRV, in blood cells of patients w...