BACKGROUND The majority of acute myocardial infarction (AMI) events are caused by thrombotic occlusion of the coronary artery, secondary to atherosclerotic plaque erosion or rupture. However, coronary embolism (CE), while rare, is being increasingly recognized as an important cause of AMI. We present the case of a patient with multi-site coronary artery embolization associated with hyperthyroid...

Myoblast implantation is a unique, patented technology of muscle regeneration being tested in Phase III clinical trials of muscular dystrophy, ischemic cardiomyopathy, Phase II trial of cancer, and Phase I trial of Type II diabetes. Differentiated and committed, myoblasts are not stem cells. Implanted myoblasts fuse spontaneously among themselves, replenishing genetically normal myofibers. They...

Sudden unexpected death is defined as a natural unexpected fatal event that occurs within 1 hour of the onset of symptoms in an apparently healthy subject or in one whose disease was not so severe as to predict such an abrupt outcome. Approximately 294 851 adults and 2000 children die of sudden unexpected death in the United States each year. Evidence from a Danish population suggests an incide...

BACKGROUND Duchenne muscular dystrophy is a fatal cardiac and skeletal muscle disease resulting from mutations in the dystrophin gene. We have previously demonstrated that a dystrophin-associated protein, sarcospan (SSPN), ameliorated Duchenne muscular dystrophy skeletal muscle degeneration by activating compensatory pathways that regulate muscle cell adhesion (laminin-binding) to the extracell...

• duchenne muscular dystrophy o onset 3 to 5 yrs o clinical § weakness o distribution § proximal > distal § symmetric § legs & arms § most involved muscles: adductor magnus in legs § relatively spared muscles: gracilis & sartorius o course § reduced motor function by 2 to 3 years § steady decline in strength: after 6 to 11 years o gowers sign: standing up with the aid of hands pushing on knees ...

background: muscle fibers overlying the intramyocardial segment of an epicardial coronary artery are termed myocardial bridge (mb). the aim of this study was to analyze the mid-term outcome of mb and to examine its possible association with angiographic findings and concomitant cardiac pathologies such as hypertrophic cardiomyopathy (hcm).   methods: from a total of 3218 patients admitted for c...

Rationale: Infantile-onset Pompe disease, also known as glycogen storage disease type II, is a progressive and fatal disorder without treatment. Enzyme replacement therapy with recombinant human acid alpha-glucosidase (GAA) enhances survival; however, the best outcomes have been achieved with early treatment. Patient concerns:We report a case of a newborn with infantile-onset Pompe disease diag...

there are few reports concerning interferon induced myocardial dysfunction. a known case of multiple myeloma who was receiving interferon alpha (ifa) for 14 months was brought to the emergency room in frank: pulmonary edema. after treatment of heart failure and discontinuation of interferon alpha, he remained asymptomatic thereafter. another case of chronic active hepatitis on ifa complained of...

road traffic accidents (rta) are one of the most important causes of death and disability all over the world. in developing countries the problem is more complicated. based on the estimation by unicef, rate of rta in iran is 20 times more than world’s average. in iran among all unintentional fatal injuries inflicted on children under five, traffic related fatalities are the leading cause of dea...

background: motor vehicle traffic injuries are indeed one of the most important worldwide health problems. opioids can induce a depressant effect on the central nervous system which may increase the risk of traffic accidents. this cross-sectional case-control study was conducted in marvdasht, iran to investigate the presence of drugs in hospitalized non-fatally injured drivers of motor vehicles...