نتایج جستجو برای: fanconi bickel syndrome

تعداد نتایج: 624826  

Journal: :Orthopedics & Traumatology 1988

Journal: :Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 2013
Jada G Hamilton Sadie P Hutson Richard P Moser Sarah C Kobrin Amy E Frohnmayer Blanche P Alter Paul K J Han

BACKGROUND Effects of different sources of medical uncertainty on people's health-related cognitions, emotions, and decision making have yet to be systematically examined. PURPOSE The aim of this study is to examine how uncertainties arising from different sources are associated with decision making regarding stem cell transplantation in Fanconi anemia, a rare, inherited bone marrow failure s...

2015
Shintaro Yamaguchi Tatsuya Maruyama Shu Wakino Hirobumi Tokuyama Akinori Hashiguchi Shinichiro Tada Koichiro Homma Toshiaki Monkawa James Thomas Kazutoshi Miyashita Isao Kurihara Tadashi Yoshida Konosuke Konishi Koichi Hayashi Matsuhiko Hayashi Hiroshi Itoh

BACKGROUND Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease, characterized by increased concentrations of serum IgM and the presence of circulating anti-mitochondrial antibodies. Although bone diseases such as osteoporosis or osteodystrophy are commonly associated with PBC, osteomalacia which is caused by abnormal vitamin D metabolism, mineralization defec...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006
Michael Ludwig Boris Utsch Leo A H Monnens

Dent’s disease 1 (OMIM 300009) is an X-linked proximal tubulopathy [1] first described in 1964 [2], with Fanconi syndrome, a consistent renal abnormality, and low-molecular-weight proteinuria (LMWP) being almost always present. Nephrocalcinosis and renal stone formation occur more frequently in Dent’s disease 1 than in other forms of Fanconi syndrome. Various features of Dent’s disease 1 predom...

Journal: :Cell 1996
Marco Pontoglio Jacqueline Barra Michelle Hadchouel Antonia Doyen Chantal Kress Joséphine Poggi Bach Charles Babinet Moshe Yaniv

HNF1 is a transcriptional activator of many hepatic genes including albumin, alpha1-antitrypsin, and alpha- and beta-fibrinogen. It is related to the homeobox gene family and is predominantly expressed in liver and kidney. Mice lacking HNF1 fail to thrive and die around weaning after a progressive wasting syndrome with a marked liver enlargement. The transcription rate of genes like albumin and...

Journal: :Rossijskij žurnal detskoj gematologii i onkologii 2023

Fanconi anemia (AF) is a hereditary genetic disease characterized by developmental abnormalities, progressive bone marrow failure, hypersensitivity to alkylating agents, and tendency hematological solid tumors throughout life. The only curative option in the treatment of failure patients with AF allogeneic hematopoietic stem cell transplantation (allo-HSCT). There are no detailed descriptions a...

Journal: :Cancer research 2015
Chantal Stoepker Najim Ameziane Petra van der Lelij Irsan E Kooi Anneke B Oostra Martin A Rooimans Saskia E van Mil Arjen Brink Ralf Dietrich Jesper A Balk Bauke Ylstra Hans Joenje Stephan M Feller Ruud H Brakenhoff

Failure to repair DNA damage or defective sister chromatid cohesion, a process essential for correct chromosome segregation, can be causative of chromosomal instability (CIN), which is a hallmark of many types of cancers. We investigated how frequent this occurs in head and neck squamous cell carcinoma (HNSCC) and whether specific mechanisms or genes could be linked to these phenotypes. The gen...

Journal: :Hormones 2005
Tasoula Tsilchorozidou John G Yovos

Osteomalacia associated with adult onset Fanconi syndrome is thought to result from hypophosphataemia due to renal phosphate loss and relative 1,25-dihydroxyvitamin D3 deficiency. In this disorder, the impaired renal phosphate uptake occurs as part of a generalized tubular defect in association with other features such as bicarbonuria, glycosuria and aminoaciduria. Fanconi syndrome is either he...

2012
Syed K. Haque Gema Ariceta Daniel Batlle

Proximal renal tubular acidosis (RTA) (Type II RTA) is characterized by a defect in the ability to reabsorb HCO(3) in the proximal tubule. This is usually manifested as bicarbonate wastage in the urine reflecting that the defect in proximal tubular transport is severe enough that the capacity for bicarbonate reabsorption in the thick ascending limb of Henle's loop and more distal nephron segmen...

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