نتایج جستجو برای: falciparum malaria
تعداد نتایج: 54272 فیلتر نتایج به سال:
BACKGROUND & OBJECTIVES The increase in Plasmodium falciparum infections which are associated with severe and complicated malaria and drug resistance has made control of malaria a difficult task. Extensive genetic polymorphism in P. falciparum has been reported from several parts of the world which affects the efficacy of sub-unit vaccines. The knowledge of genotypes of the parasite in a geogra...
Evaluation of a colorimetric PCR-based assay to diagnose Plasmodium falciparum malaria in travelers.
New diagnostic tests are needed to facilitate the diagnosis of Plasmodium falciparum malaria in the returned traveler. We performed a blinded evaluation of a nonisotopic colorimetric PCR-based assay (Digene SHARP Signal System) and compared the results with those obtained by microscopy and nested PCR for the detection of P. falciparum malaria in 150 febrile travelers. By using nested PCR as the...
We assessed monthly doses of tafenoquine for preventing Plasmodium vivax and multidrug-resistant P. falciparum malaria. In a randomized, double-blind, placebo-controlled study, 205 Thai soldiers received either a loading dose of tafenoquine 400 mg (base) daily for 3 days, followed by single monthly 400-mg doses (n = 104), or placebo (n = 101), for up to 5 consecutive months. In volunteers compl...
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BACKGROUND Early diagnosis and treatment with artesunate-mefloquine combination therapy (MAS) have reduced the transmission of falciparum malaria dramatically and halted the progression of mefloquine resistance in camps for displaced persons along the Thai-Burmese border, an area of low and seasonal transmission of multidrug-resistant Plasmodium falciparum. We extended the same combination drug...
Severe Malaria is a medical emergency mainly because of its rapid progression to complications and death if not promptly adequately treated. In 2018 WHO put the incidence P. falciparum in African region be around 99.7%.
In malaria-naïve individuals, Plasmodium falciparum infection results in high levels of parasite-infected red blood cells (iRBCs) that trigger systemic inflammation and fever. Conversely, individuals in endemic areas who are repeatedly infected are often asymptomatic and have low levels of iRBCs, even young children. We hypothesized that febrile malaria alters the immune system such that P. fal...
Conventional light microscopy has been the established method for malaria diagnosis. However, recently several nonmicroscopic rapid diagnostic tests have been developed for situations in which reliable microscopy may not be available. This study was conducted to evaluate the diagnostic performance of a recently introduced ICT Malaria Pf/Pv test. This assay detects Plasmodium falciparum histidin...
OBJECTIVE To investigate the effects of antimalarial chemoprophylaxis and other variables on the severity of falciparum malaria. DESIGN Review of consecutive malaria cases between 1987 and 1991. SETTING The Hospital for Tropical Diseases, London. SUBJECTS 250 consecutive cases of mild and 51 consecutive cases of severe falciparum malaria. RESULTS Prophylaxis was taken in 52.4% (131/250)...
Clinical manifestations of malaria cover a wide range of symptoms. Although most infected individuals will only have a relatively benign febrile illness, 1–3 million deaths per year occur due to severe malaria world wide1. This comprises severe syndromes such as cerebral malaria, severe anaemia, jaundice, renal failure, acute respiratory disstress syndrome etc. either alone or in combination2. ...
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