نتایج جستجو برای: factor forkhead box o1 foxo1

تعداد نتایج: 923682  

2014
Bo Wang Qing Yang Yuan-yuan Sun Yi-fan Xing Ying-bin Wang Xiao-ting Lu Wen-wu Bai Xiao-qiong Liu Yu-xia Zhao

Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect on diabetic cardiomyopathy. Whether the resveratrol-induced improvement in cardiac function in diabetes is via regulating autophagy remains unclear. We investigated the mechanisms underlying resveratrol-mediated protection against heart failure in diabetic mice, with a focus on the role of sirtuin 1 (SI...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2014
Song-Feng Zhao Xiao Zhang Xiao-Jian Zhang Xiu-Qin Shi Zu-Jiang Yu Quan-Cheng Kan

BACKGROUND Curcumin, a phenolic compound extracted from the rhizomes of Curcuma longa, has shown cytotoxic effects against a variety of cancers. The aim of this study was to identify potential microRNA (miRNA) mediators of the anticancer effects of curcumin in ovarian cancer cells. MATERIALS AND METHODS SKOV3 ovarian cancer cells were treated with curcumin (10-60 μM) and miR-9 expression, cel...

Journal: :The Journal of clinical investigation 2010
Zhidan Wu Ping Jiao Xueming Huang Bin Feng Yajun Feng Shengyong Yang Phillip Hwang Jing Du Yaohui Nie Guozhi Xiao Haiyan Xu

Insulin resistance results in dysregulated hepatic gluconeogenesis that contributes to obesity-related hyperglycemia and progression of type 2 diabetes mellitus (T2DM). Recent studies show that MAPK phosphatase-3 (MKP-3) promotes gluconeogenic gene transcription in hepatoma cells, but little is known about the physiological role of MKP-3 in vivo. Here, we have shown that expression of MKP-3 is ...

Journal: :International journal of oncology 2015
Terutaka Noda Tadahiko Kikugawa Nozomu Tanji Noriyoshi Miura Seiji Asai Shigeki Higashiyama Masayoshi Yokoyama

Obesity correlates with an increased risk of developing prostate cancer (PCa) and leptin plays an important role in PCa progression. Since leptin is produced by adipocytes, the serum leptin level is higher in obese than in non-obese individuals. However, the effects of leptin remain controversial and unclear. The aim of the present study was to investigate the effect of leptin on PCa cell aggre...

Journal: :Molecular pharmacology 2011
Jason Boyang Wu Jean C Shih

Valproic acid (VPA) has been widely used in clinics for the treatment of multiple neuropsychiatric disorders, such as epilepsy and bipolar disorder. One of the mechanisms by which VPA exerts its effect is through regulating the brain levels of serotonin. However, the molecular basis of this VPA action is not fully understood. Here, we report for the first time that VPA activates monoamine oxida...

Journal: :The Journal of clinical investigation 2007
Hui-Hua Li Monte S Willis Pamela Lockyer Nathaniel Miller Holly McDonough David J Glass Cam Patterson

Cardiac hypertrophy is a major cause of human morbidity and mortality. Although much is known about the pathways that promote hypertrophic responses, mechanisms that antagonize these pathways have not been as clearly defined. Atrogin-1, also known as muscle atrophy F-box, is an F-box protein that inhibits pathologic cardiac hypertrophy by participating in a ubiquitin ligase complex that trigger...

Journal: :Journal of the Endocrine Society 2021

Abstract The nutrient-sensor protein Sirtuin 1 (Sirt1; silent mating type information regulation 2 homolog 1) has been shown to have significant and opposing effects on insulin resistance, leptin body weight in the periphery brain. In hypothalamic arcuate nucleus (ARC) of brain, Sirt1 increases obese state acts promote gain as well resistance by increasing orexigenic neuropeptides Agouti-relate...

2014
Arianna Smerieri Luisa Montanini Luigi Maiuri Sergio Bernasconi Maria E. Street

Cystic fibrosis-related diabetes is to date the most frequent complication in cystic fibrosis (CF). The mechanisms underlying this condition are not well understood, and a possible role of insulin resistance is debated. We investigated insulin signal transduction in CF. Total insulin receptor, IRS1, p85 PI3K, and AKT contents were substantially normal in CF cells (CFBE41o-), whereas winged heli...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Zhongqiu Xie Mihaela Babiceanu Shailesh Kumar Yuemeng Jia Fujun Qin Frederic G Barr Hui Li

Gene fusions and fusion products were thought to be unique features of neoplasia. However, more and more studies have identified fusion RNAs in normal physiology. Through RNA sequencing of 27 human noncancer tissues, a large number of fusion RNAs were found. By analyzing fusion transcriptome, we observed close clusterings between samples of same or similar tissues, supporting the feasibility of...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید