We show how active transport of ions can be interpreted as an entropy facilitated process. In this interpretation, the pore geometry through which substrates are transported can give rise to a driving force. This gives a direct link between the geometry and the changes in Gibbs energy required. Quantifying the size of this effect for several proteins we find that the entropic contribution from ...

We describe here a transposon-based DNA sequencing strategy that allows the introduction of sequencing priming sites throughout a target sequence by bacterial mating. A miniplasmid was designed to select against transposon insertions into the vector. Sites of transposon insertion are mapped by the polymerase chain reaction with bacterial overnight cultures providing the templates. A small set o...

Background. Excimer laser coronary angioplasty has been reported to be a promising treatment for complex coronary artery disease. The purpose of this study was to define the predictors of acute success and restenosis after this experimental intervention. Methods and Resuls. A cohort of 200 consecutive patients had a minimum of 6 months of follow-up evaluation after treatment of 215 coronary ste...

We introduce a class of facilitated asymmetric exclusion processes in which particles are pushed by neighbors from behind. For the simplest version in which a particle can hop to its vacant right neighbor only if its left neighbor is occupied, we determine the steady-state current and the distribution of cluster sizes on a ring. We show that an initial density downstep develops into a rarefacti...

M ultiple, large randomised trials comparing primary percutaneous coronary intervention (PCI) with fibrinolytic therapy for ST elevation myocardial infarction (STEMI) have shown that primary PCI results in lower rates of death, reinfarction, and stroke. Consequently, primary PCI has become the preferred reperfusion strategy for STEMI. Unfortunately, primary PCI is available in only a minority o...

Virtual technology is now routinely used for meetings of large, multi-location organizations (Vandenburg and Reese, 2011), and shows great promise for bringing together geographically dispersed participants in facilitated discussions, as long as participants are familiar with the technology and comfortable using it. In most instances, it makes sense to conduct facilitated sessions in a face-to-...

Choreoathetoid movement secondary to cocaine use is a well-documented phenomenon better known as "crack dancing." It consists of uncontrolled writhing movements secondary to excess dopamine from cocaine use. We present a 32-year-old male who had been using cocaine for many years and was recently started on paroxetine, a selective serotonin reuptake inhibitor (SSRI) for worsening depression four...

The use of modeling and interactive simulations to represent complex subject matter is increasing due to the emergence of powerful new technologies. A promising methodology with an associated technology is system dynamics. System Dynamics is particularly well suited to provide the basis for meaningful learning experiences that involve learners in reasoning about relationships between the struct...