purpose: to design and manufacture iodine 125 radioactive plaques which can be used in patients with ocular melanoma, and to evaluate the efficacy of plaques in an animal model. methods: this prospective basic study was performed in collaboration with farabi hospital and tehran atomic energy agency. the iodide 125 plaques were designed and manufactured based on the collaborative ocular melanoma...

background: recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. in spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. in the presented work, the effect of utilizing an eye model with ocular media on pr...

The consideration of systemic adjuvant therapy is recommended for patients with stage IIB-IV melanoma who have undergone surgical resection due to a heightened risk experiencing relapse and mortality from melanoma. Adjuvant options tested over the past three decades include high-dose interferon-α, immune checkpoint inhibitors (pembrolizumab, nivolumab), targeted (dabrafenib-trametinib BRAF muta...

Abstract Although identified as the key environmental driver of common cutaneous melanoma, role ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 melanomas conjunctival origin by whole genome sequencing and our data shows a predominance UVR-associated single base substitution signature 7 (SBS7) majority samples. Our with SBS7 dominance have simi...

nepeta satureioides boiss. has been used in traditional medicine of eastern countries and is famous for its medicinal properties. the aim of this study was to evaluate the effect of methanol (meoh), n -hexane and dichloromethane (ch 2 cl 2 ) fractions of the extract on melanin synthesis and oxidative stress in b16f10 melanoma cell line. the b16f10 cell line viability after treatment with increa...

background: fusion of dendritic cells (dcs) with melanoma cells could reinforce the antigenicity of tumors as a strategy for the treatment of malignant melanoma. however, the insufficient quantity of dcs and the low fusion efficiency limits the development of such approach. objective: to define the dosage of the stimulating factors as well as the induction condition for the optimal dcs preparat...

Sun exposure is widely recognized as the primary etiology of cutaneous melanoma. However, melanomas also occur in skin areas unexposed to sun, such palmoplantar surface. Little known about risk factors and mutational processes acral melanoma; however, they frequently at points higher mechanical stress on hand foot, suggesting a contributing factor for plantar melanoma development. Furthermore, ...

Ocular melanoma (OM) is a rare noncutaneous malignancy and consists of 2 different subtypes based on the anatomic location in eye: uveal conjunctival melanoma. Like cutaneous melanoma, OM benefits from nuclear medicine molecular imaging nodal staging clinical management. Through illustration distinctive cases, we aim to demonstrate complementary roles standard lymphoscintigraphy, advanced SPECT...

COVID-19 pandemija sutrikdė ir apribojo visą sveikatos priežiūrą, ypač planinę, tarp jos onkologinę pagalbą, o kartu pagalbą sergantiems melanoma. Darbo tikslas – ištirti palyginti pacientų, sergančių melanoma, stacionarinės medicinos pagalbos prieina­mumą iki pandemijos (2019) (2020) metais. Analizuotos įvairių šalių autorių mokslinės publikacijos nagrinėjama tema, tirtos melanoma sirgusių pac...

Early detection of melanoma is a vital determinant in achieving favorable prognosis and patient outcomes which led to innovations skin imaging modalities that improved the diagnostic accuracy early melanoma. Studies reported cancer its stages using dermoscopy reflectance confocal microscopy, however there are limited reports detecting micro-melanomas less than 2-mm diameter. Previously, smalles...