In the past two decades, the repair and reconstruction of musculoskeletal tissues using biodegradable scaffold materials has emerged as one of the most promising approaches in tissue engineering. The aim of this study is to process, via hot melt extrusion, the biodegradable and biocompatible polymeric materials; poly(ethylene oxide) (PEO), poly(ethylene glycol) (PEG), ⍺lactose monohydrate and p...

A novel multi-functional vertical high shear kneader has been developed. Wet kneading of pharmaceutical powders was conducted under various blade components and operating conditions. Compression properties of wet kneaded mass was analyzed and dispersion of hinder liquid (water) among the mass was investigated by assaying tracer aqueous pigment. Pellets were produced through a dome type extrusio...

The present work aims to predict drug release from novel site-specific release isoniazid pellets, in USP dissolution test apparatus 3, using the response surface methodology (RSM). Site-specific release isoniazid pellets were prepared by extrusion-spheronization followed by aqueous coating of Acryl-EZE. RSM was employed for designing of the experiment, generation of mathematical models and opti...

Three processed lactose-cellulose blends of similar composition, particle size and true density were compared as direct compression excipients: one was prepared by dry granulation, one by extrusion-spheronization, and the commercial product Cellactose. Differences among their flow properties depended solely on their different sphericities. Unlike those of the other blends, Cellactose particles ...

The present study was designed to investigate the effect of different types of coating polymers such as Eudragit RL 30D, Eudragit RS 30D, Eudragit NE 30D, Surelease, and Kollicoat SR 30D on physical properties and release pattern of salbutamol sulphate (SS) pellets which were prepared by Extrusion-Spheronization technology. All the polymers used in coating solution were in aqueous dispersion fo...