a male patient in his 20s presented at our clinic with pain caused by bone metastases of the primitive neuroectodermal tumor, and sr-89 was administrated to palliate the pain. after receiving the injection, the patient complained of a slight burning pain at the catheterized area. slight reddening and small circular swelling (diameter, 0.5 cm) were observed at the catheterized area. sr-89 extrav...

Children receiving intravenous (IV) fluids, electrolytes and antibiotics are particularly prone to fluid escape (extravasation). Extravasation of chemotherapeutic agents, hypertonic fluids, sodium bicarbonate and calcium salts cause skin ulceration and necrosis(l). Children who are irritable or getting repeated seizures are more prone to IV bulge and fluid escape at the site, because of their t...

Anthracycline chemotherapy agents bind to DNA and cause cell death when they extravasate into healthy tissue. Although many approaches to managing extravasations have been studied and reported, data from two prospective clinical trials suggest that TotectTM (dexrazoxane for injection, TopoTarget USA, Inc.) is an effective anthracycline extravasation treatment. Only 1 of 54 patients with doxorub...

A deeper understanding of the mechanisms of tumor cell extravasation is essential in creating therapies that target this crucial step in cancer metastasis. Here, we use a microfluidic platform to study tumor cell extravasation from in vitro microvascular networks formed via vasculogenesis. We demonstrate tight endothelial cell-cell junctions, basement membrane deposition and physiological value...

Conventional angiography is used to evaluate and treat possible sources of intraabdominal bleeding, though it may cause complications such as contrast-induced nephropathy (CIN). The study's purpose was to identify factors predicting active extravasation and complications during angiography for acute intraabdominal bleeding. All conventional angiograms for acute bleeding (January 2013-June 2015)...

The infiltration of inflamed tissues by leukocytes is a key event in the development and progression of inflammation. Although individual cytokines, which coordinate extravasation, have become the targets for therapy, a mechanism that is common to white cell extravasation, regardless of the specific molecular mechanism involved, would represent a more attractive therapeutic target. Such a targe...

Cancer metastases arise following extravasation of circulating tumor cells with certain tumors exhibiting high organ specificity. Here, we developed a 3D microfluidic model to analyze the specificity of human breast cancer metastases to bone, recreating a vascularized osteo-cell conditioned microenvironment with human osteo-differentiated bone marrow-derived mesenchymal stem cells and endotheli...

A case report demonstrating urine extravasation into the scrotum following renal transplantation is presented. An anatomic explanation of the pathway of urine drainage into the scrotum is offered with a brief discussion of extravasation following renal transplantation and its detection by scintigraphy.