Rosai-Dorfman disease (RDD) is a rare lymphoproliferative disorder with nodal and extranodal involvements. Here we report a case of RDD in a 15-year-old female who presented with epigastric pain, fatigue, Raynaud phenomenon in fingers, submandibular lymphadenopathy, proptosis, hepatosplenomegaly, and round shape painless patches on the extensor surfaces. Histological examination of the submandi...

CRDD: cutaneous Rosai-Dorfman disease RDD: Rosai-Dorfman disease INTRODUCTION Rosai-Dorfman disease (RDD) is a benign nonLangerhans cell histiocytic disorder often involving the cervical lymph nodes. Extranodal disease was reported in 43% of patients with RDD in a review of the literature, with the skin reported to be the most common extranodal site. In the absence of lymph node involvement, RD...

Background: Lymphoma arises in lymph nodes. Infiltration of malignant lymphomatous cells the organs other than node is termed as extranodal lymphoma (ENL). Almost any organ body can get affected. The most frequently involved system gastrointestinal tract, followed by lung, liver, spleen, bone, and skin. Primary central nervous (CNS) also well documented. Origin tumor from non-lymph-nodal tissue...

Extranodal natural killer (NK)/T-cell lymphoma is a very rare and aggressive disease characterized histopathologically by an Epstein-Barr virus (EBV)-positive atypical lymphoid cytotoxic infiltrate, extensive vascular destruction, and prominent tissue necrosis. It commonly shows cutaneous lesions that primarily or secondarily mimic cellulitis at the primary site. We report on a very rare case o...

Extranodal natural killer (NK)/T-cell lymphoma is a very rare and aggressive disease characterized histopathologically by an Epstein-Barr virus (EBV)-positive atypical lymphoid cytotoxic infiltrate, extensive vascular destruction, and prominent tissue necrosis. It commonly shows cutaneous lesions that primarily or secondarily mimic cellulitis at the primary site. We report on a very rare case o...

Rosai-Dorfman disease is a rare condition of marrow hematopoietic stem-cell origin. Patients can show extranodal involvement as well as lymphatic involvement, but only about 5% of extranodal cases involve intracranial lesions. A 53-year-old male was admitted to our hospital with bilateral cervical lymphadenopathy. Intracranial tumors and bone lesions were also detected. Cervical lymph node biop...

Non-Hodgkin lymphomas (NHL) often show up in an extranodal pattern, especially in the head and neck. Intraoral locations are much less frequent, particularly when they are single. This, in turn, can lead to a prolonged diagnosis and even to inadequate treatment. Different patients with initial extranodal location of NHL which were not previously diagnosed and in which it was manifested only int...