To characterize Ca(2+)-mediated synaptic vesicle fusion, we analyzed Drosophila synaptotagmin I mutants deficient in specific interactions mediated by its two Ca(2+) binding C2 domains. In the absence of synaptotagmin I, synchronous release is abolished and a kinetically distinct delayed asynchronous release pathway is uncovered. Synapses containing only the C2A domain of synaptotagmin partiall...

Objectives: Trigger finger in pediatric patients is not as commonly seen as it is in adults. With that, it is ten times less likely to be seen than trigger thumb. Trigger finger usually presents in children less than 8 years old. It may be associated with anatomic, metabolic, inflammatory, and central nerve disorders. Flexion deformity of the finger is reported as the most frequent presentation...

     In this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (PLGA 50:50) and poly (lactide). The effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation effic...

The ultrasound-induced cleavage of covalent and non-covalent bonds to activate drugs (sonopharmacology) is a promising concept gain control over the action active pharmaceutical ingredients by an external trigger. Previously, linear polymer architectures bearing drug payloads were exploited for release using principles mechanochemistry. In this work, carrier design altered topology improve ultr...

Purpose: This study investigated the effect of myofascial release in relieving the symptoms of Chronic Tension Type Headache (CTTH) Methods: The study used a convenience sampling pretest-post test design. 31 people (7 men and 24 women, age range 18-58 years, mean age 32 years) with CTTH participated in the study. The headache sample was screened for MTrP in the cranial and pericranial muscles a...

The purpose of this retrospective study was to compare the outcomes and complications of conventional open surgical release and percutaneous needle release in the treatment of trigger thumb. The study comprised 87 patients with trigger thumb who were treated with either open pulley (n=52) or percutaneous (n=32) release between 2008 and 2011. All patients were reevaluated at a mean follow-up of ...

Objective: The purpose of this study was to determine the immediate effect of ischaemic compression, trigger point pressure release and placebo ultrasound on pain, degree of cervical lateral flexion and pressure pain threshold of upper trapezius trigger points in subjects with non-specific neck pain. Design: Randomised, single-blind, placebo-controlled trial. Setting: Anglo-European College of ...

OBJECTIVE. To evaluate results from surgical release of trigger thumbs in children in a regional hospital cluster in Hong Kong. DESIGN. Descriptive case series. SETTING. A regional hospital cluster, Hong Kong. PATIENTS. Data from 1993 to 2009 on 180 children with 209 trigger thumbs were collected. Analyses into gender, predominance of thumb, age of onset, associated abnormalities and family his...

in this research, we investigated the cytotoxic mechanisms of one of the widely used pharmaceuticals that are regularly associated with the adverse effects on the liver, sometimes leading to acute liver failure, diclofenac. diclofenac liver cytotoxicity was associated with reactive oxygen species (ros) formation and lipid peroxidation which were inhibited by antioxidants and ros scavengers, fer...

Stimuli-responsive biomaterials have attracted significant attention in the field of polymeric implants designed as active scaffolds for on-demand drug delivery. Conventional porous scaffolds suffer from drawbacks such as molecular diffusion and material degradation, allowing in most cases only a zero-order drug release profile. The possibility of using external stimulation to trigger drug rele...