background: recent studies indicate an increased incidence of pertussis disease in recent years. the aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the expanded program on immunization) and for high-risk adults in iran through updating current best available evidence.   methods: we performed a systematic li...

background & aim: the recent study was conducted to investigate the effects of thyme extract in drinking water on immune response of broiler chickens. experimental:  a total of 245 day-old broiler chicks were purchased and 20 chicks were bled for determination maternal antibody and remaining chicks divided into 5 equal groups. chickens of group a, b and c received 0.1%, 0.15% and 0.2% ofthy...

The history of the development of influenza virus vaccine is traced from its origin with experimental studies of influenza virus in ferrets and mice and the first trials in man. Knowledge of the basis of immunity to the viruses in experimental animals and in man has grown steadily over the years and has been essential to successful immunization. Virus variation affecting the surface antigens of...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 aim : in this study we co-administered melittin along with hbsag/alum vaccine to investigate if it helps elicitation of th1/th2 response. background : hepatitis b virus (hbv) infection is a life-threatening liver infection, which can lead to chronic l...

We study the impact of vaccine hesitancy on take up COVID-19 immunization campaign in Italy. Our empirical strategy exploits a quasi-experiment that occurred with temporary suspension AstraZeneca (AZ) March 2021. Before interruption, AZ vaccination trend followed same pattern as Pfizer-Biontech (PB). document that, after was lifted, injections two vaccines started to diverge, following declinin...

Eukaryotic pathogens typically follow a complex life cycle, including host switch and morphologically distinct forms. Parasite stage conversion offers exceptional opportunities for whole organism vaccine development. In case of Plasmodium, the causative agent of malaria, disease is exclusively caused by asexual blood stages that invade and replicate within erythrocytes. Pathogenic blood stage i...

There is an urgent need for pre-clinical and clinical biomarkers predictive of vaccine immunogenicity, efficacy and safety to reduce the risks and costs associated with vaccine development. Results emerging from immunoprofiling studies in non-human primates and humans demonstrate clearly that (i) type and duration of immune memory are largely determined by the magnitude and complexity of the in...