The use of antimony compounds, particularly potassium antimonyl tartrate (Tartar emetic), in Cryptococcosis has occasionally been mentioned in the literature,2"' but no experimental study of the therapeutic rationale of the use of antimonials in this infection has to our knowledge ever been under-taken. It did not seem that Tartar emetic was of any therapeutic value, but this should not reflect...

metry please, hydramnios; and what constituted a positive radiological correlation in such cases? The method used for scoring agreements in this study (stated simply as "whether the radiological interpretation agreed with the clinical diagnosis as stated on the request card") is not clearly defined (except when nothing was detected on a routine-no pathology suspected-request). Perhaps the autho...

Noroviruses are the most common cause of viral gastroenteritis in the United States. To determine the magnitude and duration of virus shedding in feces, we evaluated persons who had been experimentally infected with Norwalk virus. Of 16 persons, clinical gastroenteritis (watery diarrhea and/or vomiting) developed in 11; symptomatic illness lasted 1-2 days. Virus shedding was first detected by r...

BACKGROUND Members of the CD36 scavenger receptor family have been implicated as sensors of microbial products that mediate phagocytosis and inflammation in response to a broad range of pathogens. We investigated the role of CD36 in host response to mycobacterial infection. METHODS Experimental Mycobacterium bovis Bacillus Calmette-Guérin (BCG) infection in Cd36+/+ and Cd36-/- mice, and in vi...

1. Eight rhesus monkeys with experimental poliomyelitis following intrasciatic inoculation of "M.V." virus were used to study the extent of virus spread in the central and peripheral nervous systems and the question of its elimination in the nasal secretions. 2. Tests on nasal secretions collected on absorbent cotton plugs daily and continuously from the moment of inoculation to the end of the ...

Infectivity and pathogenicity of Bordetella bronchiseptica to rabbits were investigated by intranasal inoculation of the organism to suckling and young animals. Results are summarized as follows. 1. By inoculation of 5 X 10(4) and 10(6) organisms, the infection developed in 60% and 100% of young rabbits, respectively. 2. In young rabbits, the growth of the organism was evident in the trachea wi...

Experimental models of Schistosoma mansoni infections in mammals have contributed greatly to our understanding of the pathology and pathogenesis of infection. We consider here hepatic and extrahepatic disease in models of acute and chronic infection. Experimental schistosome infections have also contributed more broadly to our understanding of granulomatous inflammation and our understanding of...

We established a human burn isolate of Proteus mirabilis as an experimental pathogen. Infliction of a nonfatal scald injury (30%) rendered rats highly susceptible to lethal surface infection with this isolate. Dose-response experiments indicated that the lethal inoculation dose (50%) was less than 10(3) organisms per square centimeter. Histopathologically, surface colonization was followed by p...

The pathogenesis of Mycoplasma pneumoniae infection was studied in the Syrian hamster with qualitative and quantitative culture methods and special histopathologic techniques. The animals were readily infected with the mycoplasma, which multiplied throughout the respiratory tract. Sensitivity of this experimental host to infection was indicated by the 50 per cent infective dose, which was 10 co...

1. A strain of meningococci obtained directly from the spinal fluid of a patient has been propagated in serial passage in 10 to 12 day old chick embryos without change in its essential characteristics. 2. The chick embryo is susceptible to infection with the meningococcus, and, depending on its stage of development, reacts to the infection with more or less specific lesions. 3. In chick embryos...