objective: anti-inflammatory, immuno-modulatory, and antioxidant properties of moringa oleifera lam. suggest that it might have beneficial effects on colitis. the present study was performed to investigate the anticolitis effect of moringa oleifera seeds hydro-alcoholic extract (mshe) and its chloroform fraction (mcf) on acetic acid-induced colitis in rats. materials and methods: both mshe and ...

trinitrobenzene sulfonic acid (tnbs)-induced colitis is one of the most common methods for studying inflammatory bowel disease in animal models. several factors may, however, affect its reproducibility, rate of animal mortality, and macroscopic and histopathological outcomes. our aim was to validate the main contributing factors to this method and compare the effects of different reference drug...

Inflammatory bowel disease (IBD) arises by unknown environmental triggers in genetically susceptible individuals. Epigenetic regulation of gene expression may integrate internal and external influences and may thereby modulate disease susceptibility. Epigenetic modification may also affect the germ-line and in certain contexts can be inherited to offspring. This study investigates epigenetic al...

Imbalance in gut bacterial composition provokes host proinflammatory responses causing diseases such as colitis. Colonization with a mixture of Clostridium species from clusters IV and XIVa was shown to suppress colitis through the induction of IL-10-producing regulatory T (Treg) cells. We demonstrate that a distinct Clostridium strain from cluster I, Clostridium butyricum (CB), prevents acute ...

AIM To investigate the therapeutic effect of Schistosoma mansoni (S. mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS Colitis was induced by intrarectal injection of trinitrobenzene sulphate (TNBS) and 6 h later, mice were treated ip with S. mansoni proteins. Experiments were performed 5 d after TNBS injection. Inflammation ...

Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted to systematically review the medicinal plants tested in experimental models of ...

The aim of this study was to test the therapeutic efficacy of sodium alginate in a rat model of trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease. This experiment was carried out using 77 Sprague-Dawley rats which were divided into six groups; normal, control, prophylactic, therapeutic and two experimental groups. Rats were sacrificed 1, 2, 3 and 6 weeks after colitis indu...

Cold plasma discharges have been shown to have medically-relevant therapeutic effects when applied to living tissues, including blood coagulation and wound healing; thus, plasma treatment of infl amed tissues in ulcerative colitis disease may be an effective approach to reduce adverse consequences if not cure the disease. Here we discuss results of the fi rst experimental study of cold plasma t...

• Numerous therapies used for inflammatory bowel disease (IBD) target the transcription factor NFkappaB, which is involved in the production of cytokines and chemokines integral for inflammation. The authors show that curcumin, is able to attenuate colitis in the dinitrobenzene sulfonic acid (DNB)-induced murine model of colitis. They also show that the immunohistochemical signal is dramaticall...

The therapeutic potential of tonsil-derived mesenchymal stem cells (TMSC) prepared from human tonsillar tissue has been studied in animal models for several diseases such as hepatic injury, hypoparathyroidism, diabetes and muscle dystrophy. In this study, we examined the therapeutic effects of TMSC in a dextran sulfate sodium (DSS)-induced colitis model. TMSC were injected in DSS-induced coliti...