Whereas approximately half of metastatic melanoma patients benefit from combined immune checkpoint inhibition targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed cell death 1 (PD-1), for those who do not respond, further strategies treatment options need to be developed. Thus, focus is turning the use chimeric antigen receptor (CAR) T cells, a novel therapy that has ye...

In this paper, we present new ways to interact with a computer similar to driving a car and compare these techniques to the standard ways to control the computer like mouse and keyboard. We think that controlling the computer with both hands and feet in the same way that one controls a car offers new possibilities especially for three dimensional (3D) World Wide Web (WWW) navigation. The car me...

Holding non-co-located conversations while driving is dangerous (Horrey and Wickens, 2006; Strayer et al., 2006), much more so than conversations with physically present, “situated” interlocutors (Drews et al., 2004). In-car dialogue systems typically resemble non-co-located conversations more, and share their negative impact (Strayer et al., 2013). We implemented and tested a simple strategy f...

The general framework of this research is about risk awareness through the aspect of cognitive abilities to perceive and assess the criticality of the driving situation among motorcyclists versus car drivers. In order to study risk awareness, we have developed some tools based on video films. The experimental task consists in assessing the criticality of dynamic driving situations, via a Likert...

reviews in many countries indicate that drivers often talk on mobile (cell) phones. studies have been done on possible effects of concurrent mobile phone use on driving performance. previous studies have found that phone talking could impairs performance on simulated or instrumented driving tasks, using such measures as reaction time, following distance, and situational awareness. most of these...

In Mexico Ciy, a ban restricting each car from driving on a specified work-The "Day Without a Car" day actually increased total in Mexico City driving and congestion. In November 1989, Mexico City's administration Some feel that it may be so inefficient that it is imposed a regulation banning each car from driving on a counterproductive. And Eskeland and Feyzioglu found specific day of the week...