Article history: Received 8 June 2015 Accepted 8 June 2015 Available online 10 June 2015 such as the aorta, heart and brain as well as potentially deleterious hyperhomocystinemia in PES-positive subjects (for references see Slettedal et al., 2015). Such claims have independently been challenged by data from other centers, which also has spoken against a clinically significant, true association ...