نتایج جستجو برای: ewing

تعداد نتایج: 2735  

Hooshang Ehsani, Mehdi Tahvildari, Mohsen Khalili,

A l4 - year - old male patient with ewing sarcoma is presented and discussed, specially in respect of lo­calization and progress of the tumor.  Radiologic, bioptic, treatment and complica­tions of the disease are also discussed. 

Journal: :Cancer research 2000
K Scotlandi N Baldini V Cerisano M C Manara S Benini M Serra P L Lollini P Nanni G Nicoletti G Bernard A Bernard P Picci

CD99 is a Mr 32,000 transmembrane molecule that shows a high level of expression on cells of the hemopoietic system as well as on Ewing tumor cells. Within the hematopoietic system, CD99 has been implicated in cell adhesion and cell death, participating in this way in the differentiation of T-cell precursors. In this study, we demonstrate that engagement of CD99 significantly inhibits the in vi...

Journal: :Cancer genetics and cytogenetics 2006
Károly Szuhai Marije Ijszenga Hans J Tanke Carla Rosenberg Pancras C W Hogendoorn

Most Ewing family tumors are identified by the characteristic translocation t(11;22)(q24;q12), resulting in a fusion protein EWS/FLI1 that acts as an aberrant transcription factor. In a minority of cases, the EWS gene is fused to another member of the ETS gene (ERG, ETV1, E1AF, and FEV). Though the oncogenic transforming capability of the EWS/FLI1 protein is highly suggestive, the exact pathway...

2010
Faten Hammedi Sonia Ziadi Mounir Trimeche Wafa Jomaa Baddredine Sriha Sadok Korbi

Background Extraskeletal Ewing's sarcoma is a rare malignant tumor of mesenchymal origin, which is histologically similar to primary osseous Ewing's sarcoma. It has been well described in deep soft tissues. However, location in cutaneous or subcutaneous tissue has rarely been reported. Being seen principally in children, it can be seen, rarely, in old men. Case report We present a case of sub...

2016
Md. Jawed Akther L. Udaya Kumar Shameem Unnisa Shaikh

When Ewing’s sarcoma arises in soft tissue rather than bone, it is referred to as extraskeletal Ewing’s sarcoma (ESS). It is generally accepted to be between 15% and 20% of that of Ewing sarcoma of bone. Extraskeletal Ewing sarcoma usually manifests in young patients, with 85% of cases detected between 20 months and 30 years of age. The most commonly reported locations of extraskeletal Ewing sa...

2015
John Fadul Russell Bell Laura M. Hoffman Mary C. Beckerle Michael E. Engel Stephen L. Lessnick

In Ewing sarcoma, NKX2-2 is a critical activated target of the oncogenic transcription factor EWS/FLI that is required for transformation. However, its biological function in this malignancy is unknown. Here we provide evidence that NKX2-2 mediates the EWS/FLI-controlled block of mesenchymal features. Transcriptome-wide RNA sequencing revealed that NKX2-2 represses cell adhesion and extracellul...

Journal: :World journal of surgical oncology 2016
Qing Ting Tan Jin Yao Teo Syed Salahuddin Ahmed Alexander Yaw Fui Chung

BACKGROUND Ewing sarcomas are highly aggressive malignant tumours occurring predominantly in the long bones of the extremities in children and young adults. About 20 % of patients will present with metastases at diagnosis with the commonest sites being the lungs, bone and bone marrow. Cases of primary small bowel Ewing sarcomas have been described but are nonetheless exceedingly rare, even more...

2014
Preetam Gongidi Siva Jasti William Rafferty Veniamin Barshay Richard Lackman

Ewing sarcoma of bone is classically a permeative lesion in the diaphysis of long bones in children. While they occur primarily in children and adolescents, they can be seen in young adults in their 20s, but these are typically seen in flat bones. The permeative nature of the lesion can elicit new bone formation creating a partially sclerotic appearance, cortical expansion presenting as a "Codm...

2012
J. Abawajy A. V. Kelarev A. Stranieri H. F. Jelinek

This article is devoted to an empirical investigation of performance of several new large multi-tier ensembles for the detection of cardiac autonomic neuropathy (CAN) in diabetes patients using subsets of the Ewing features. We used new data collected by the diabetes screening research initiative (DiScRi) project, which is more than ten times larger than the data set originally used by Ewing in...

2015
Ana M. Sanchez-Sanchez Isaac Antolin Noelia Puente-Moncada Santos Suarez Marina Gomez-Lobo Carmen Rodriguez Vanesa Martin David M Loeb

Melatonin kills or inhibits the proliferation of different cancer cell types, and this is associated with an increase or a decrease in reactive oxygen species, respectively. Intracellular oxidants originate mainly from oxidative metabolism, and cancer cells frequently show alterations in this metabolic pathway, such as the Warburg effect (aerobic glycolysis). Thus, we hypothesized that melatoni...

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