In this study, we investigated the effects of polymers on pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as active ingredient (API), nicotinamide (NIC) and saccharin (SAC) coformer (CCF), ethanol/water solvent, polyvinylpyrrolidone (PVP) poly (ethylene glycol) (PEG) representative polymers. We prepared IBU-NIC IBU-SAC cocrystals in ethanol-water cosolvent absence or pr...

regioselective synthesis of highly functionalized pyranopyrazoles was achieved in excellent yield from phenyl pyrazolone, substituted aromatic aldehyde with nitroketene-n,s-acetal in the presence of indium trichloride as a versatile catalyst under reflux condition in ethanol-water mixture. all reactions preceeded within a short period of time with excellent purity. all of the synthesized compou...

A fast, clean and easy to automate flow injection-pervaporation method for the determination of ethanol in different beverages using density measurements is proposed. The method is based on separation of the ethanol from the sample using a pervaporation module; the analyte being collected in water as acceptor liquid. The density of this water-alcohol mixture is measured at the detector. After o...

The low aqueous solubility of celecoxib (CB) and thus its low bioavailability is a problem. Thus, it is suggested to improve the solubility using cosolvency and solid dispersions techniques. Pure CB has solubility of 6.26±0.23μg/ml in water but increased solubility of CB was observed with increasing concentration of cosolvents like PEG 400, ethanol and propylene glycol. Highest solubility (791....

The effect of fat rich (F), protein rich (P) and carbohydrate rich (C) diets and chronic ethanol consumption on experimental acute pancreatitis was studied in rats. One hundred and ninety two animals with induced acute pancreatitis were divided into eight groups fed either a mixture of water and 15% ethanol (v/v), or tap water combined with standard or special diets according to their group, fo...

Nanosized rare earth (RE) hydroxides including La(OH)3, Nd(OH)3, Pr(OH)3, Sm(OH)3, Gd(OH)3, and Er(OH)3 with rod-like morphology are fabricated via a convenient hydrothermal approach. This strategy calls for the first preparation of metal complexes between RE precursors and dodecylamine (DDA) in water/ethanol mixture at room temperature and subsequent thermal decomposition at elevated temperatu...

RESUMO – This work aimed the evaluation of a saline extractive distillation for the ethanol production. Unlike the current method of dehydration of ethanol, which uses a solvent, distillation with the use of salt does not include problems related to toxicity and has lower power consumption, since salt is not volatilized within the distillation column. Many salts had been tested like calcium chl...

Ethanol production from corn starch in the corn dry milling process leaves Distillers' Dry Grains and Solubles (DDGS) as a major by-product from which additional ethanol may be economically obtained from its glucan content. A challenge in processing the cellulose content of this material lies in its extensive inter-cellulose chain hydrogen bonding, which inhibits access of enzymes capable of cl...