To elucidate the pathophysiologic role of endogenous endothelin (ET)-1 in acute respiratory failure, we measured plasma immunoreactive ET-1 levels in 13 patients with acute respiratory failure, and compared those with hemodynamic and respiratory parameters. The mean plasma ET-1 levels (10.7 +/- 5.0 pg/ml) in 13 patients with acute respiratory failure at the time of hospital admission were about...

Gheorghiade M et al. Nitrate therapy forheart failure: benefits and strategies to overcome tolerance. JACC Heart Fail 2013;1:183–91. 23. Rijnierse MT, de Haan S, Harms HJ, Robbers LF, Wu L, Danad I et al. Impaired hyperemic myocardial blood flow is associated with inducibility of ventricular arrhythmia in ischemic cardiomyopathy. Circ Cardiovasc Imaging 2014;7: 20–30. 24. Levy D, Kenchaiah S, L...

aminoterminal pro-brain natriuretic peptide testing for the diagnostic and prognostic evaluation of dyspneic patients with diabetes mellitus seen in the emergency department (from the PRIDE study). Am J Cardiol 2007;100:1336–40. 4. Azevedo A, Bettencourt P, Pimenta J, et al. Clinical syndrome suggestive of heart failure is frequently attributable to non-cardiac disorders—population-based study....

Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstrictor currently known. ET-1 also has inotropic, chemotactic and mitogenic properties. In addition, it...

BACKGROUND Elevated plasma endothelin-1 (ET-1) levels in patients with chronic heart failure correlate with pulmonary artery pressures and pulmonary vascular resistance. ET(A) receptors on vascular smooth muscle cells mediate pulmonary vascular contraction and hypertrophy. We determined the acute hemodynamic effects of sitaxsentan, a selective ET(A) receptor antagonist, in patients with chronic...

In the present study, we tested a computer-based procedure for assessing very concise summaries (50 words long) of two types of text (narrative and expository) using latent semantic analysis (LSA) in comparison with the judgments of four human experts. LSA was used to estimate semantic similarity using six different methods: four holistic (summary-text, summary-summaries, summary-expert summari...

Le langage logique est celui de la logique du second ordre, avec des symboles de fonctions et des variables et constantes de prédicat sur les individus. Les seuls symboles logiques sont →,∀. Définitions. ⊥≡∀X X ; ¬A ≡ A →⊥ ; A∧B ≡¬(A,B →⊥) ; A∨B ≡¬A,¬B →⊥ ; ∃x A ≡¬∀x¬A ; ∃X A ≡¬∀X¬A ; t = u ≡∀X (X t → X u). On écrira A1, A2, . . . , Ak → A pour A1 → (A2 → (. . . (Ak → A) . . .)). On écrira ∃x{A...

These guidelines for the management of lichen sclerosus have been prepared for dermatologists on behalf of the British Association of Dermatologists. They present evidence-based guidance for treatment, with identification of the strength of evidence available at the time of preparation of the guidelines, and a brief overview of epidemiological aspects, diagnosis and investigation.