Estrogens promote a plethora of effects in the CNS that profoundly affect both its development and mature functions and are able to influence proliferation, differentiation, survival and neurotransmission. The biological effects of estrogens are cell-context specific and also depend on differentiation and/or proliferation status in a given cell type. Furthermore, estrogens activate ERK1/2 in a ...

Five biopsy specimens of morphologically normal human breast tissues, obtained from the margins of five benign human breast tumors, were processed into slices (4.0 x 4.0 x 0.1 mm) and transplanted s.c. dorsally (eight to ten slices/mouse) into forty-three 6- to 8-week-old female BALB/c athymic nude mice. Each individual human breast tissue specimen was transplanted into seven to ten mice. After...

The mammalian testis is a complex organ that serves two important functions, synthesis of steroids, with significant amount of estrogenic hormones produced and production of spermatozoa. Estrogen receptors (ERs) are expressed in cells of the testis as well as the epididymal epithelium. We have demonstrated that estrogen receptor expression is higher in reproductive tissues as compared to non-re...

The presence of hormones, drugs and chemicals in the environment are disrupting ecosystem. existence is a threat to ecosystem as they have dangerous effects on animals, plants microbes. Progesterones steroid hormones used for human contraceptives therapeutic purposes well promoting animal growth. cases consumption progesterone medical much higher than estrogens, however, studies related estroge...

Urinary three estrogens (estrone, estradiol-17 [3 and estriol) in patients with advanced breast cancer before and after oophorectomy and adrenalectomy were chemically determined in an attempt to evaluate response of cancer to the surgery and its subsequent relapse. Results are as follows: 1. The existence of adrenal estrogens was evidenced indirectly in control subjects. 2. The high levels of p...

In the course of a study of various procedures for the concentration and purification of urinary estrogens, the feasibility of the chromatographic technique seemed to warrant investigation. Chromatography has been employed to advantage in isolation procedures (l-3) for certain estrogens but no attempt has been made to utilize it in any quantitative procedure for estrone, estriol, and cY-estradi...

Venous thromboembolism (VTE) is a major harmful effect of hormone therapy (HT) among postmenopausal women. A large variety of HT can be used with significant differences in adverse effects. There is evidence that the VTE risk among HT users depends on the route of estrogen administration. Oral but not transdermal estrogens dose-dependently increase the VTE risk. This difference is supported by ...

The presence of estrogens in livestock excrement has raised concerns about their potential negative influence on animals and the overall food cycle. This is the first investigation to simultaneously remove estrogens, including estriol (E3), bisphenol A (BPA), diethylstilbestrol (DES), estradiol (E2), and ethinyl estradiol (EE2), from cow manure using a Fenton oxidation technique. Based on the r...

Five biopsy specimens of morphologically normal human breast tissues, obtained from the margins of five benign human breast tumors, were processed into slices (4.0 x 4.0 x 0.1 mm) and transplanted s.c. dorsally (eight to ten slices/mouse) into forty-three 6to 8-week-old female BALB/c athymic nude mice. Each individual human breast tissue specimen was trans planted into seven to ten mice. After ...