SUMMAR,Y Incubation of human serum solutions low in glyceride content for 16 hr resulted in a net increase of cholesterol esters in all three major human serum lipoprotein classes, namely the very low-density lipoproteins of d < 1.006 (VLDL), low-density lipoproteins of d 1.006-1.063 (LDL) and highdensity lipoproteins of d 1.063-1.21 (HDL). Transfer of glycerides from the VLDL to the LDL and HD...

5-Lipoxygenase (5-LO) is the key enzyme responsible for the conversion of arachidonic acid to leukotrienes, a class of lipid mediators implicated in inflammatory disorders. In this paper, we describe the design, synthesis, and preliminary activity studies of novel clicked caffeic esters and amides as radical scavengers and 5-LO inhibitors. From known 5-LO inhibitor 3 as a lead, cinnamic esters ...

Rates of peroxisomal beta-oxidation were measured as fatty acyl-CoA-dependent NAD+ reduction, by using solubilized peroxisomal fractions isolated from livers of rats treated with clofibrate. Medium- to long-chain saturated fatty acyl-CoA esters as well as long-chain polyunsaturated fatty acyl-CoA esters were used. Peroxisomal beta-oxidation shows optimal specificity towards long-chain polyunsat...

A. Marston and E. Hecker***** Institut für Biochemie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900 Heidelberg, FRG Z. Naturforsch. 38b, 1015-1021 (1983); received March 28, 1983 Amino Acids, Peptides, Phorbol Esters, Irritants, Tumour Promoters The synthesis of a series of 12-O-amino acyland 12-0-peptidyl-13-acetate and -13,20diacetate esters of the tetracyclic diterpene al...

The nucleophilic ring opening of epoxy fatty esters was carried out using the amino-1,2,4-triazole to yield substituted derivatives of β-amino alcohol. The synthesis of the substituted beta amino alcohols has been achieved by refluxing equimolar quantities of long chain epoxy esters (epoxy fatty esters) and 4-amino-1,2,4-triazole in dichloromethane to yield following compounds, methyl 10-(4'-am...

The effect of phorbol esters on the light-evoked responses of horizontal cells were studied in the turtle eyecup preparation. Phorbol esters caused a reduction in receptive field size and a significant decrease in the amplitude of responses to annular and full-field illumination; however, they caused only minor changes in responses to small spots in the receptive field centre. The dark membrane...

Previous work has shown that cholesterol esters are relatively insoluble (<5 mol%) in bilayer phosphatidylcholine and sphingomyelin systems, but exhibit greater solubility in hexagonal (HII) phase anhydrous phosphatidylcholine systems obtained above 100°C. We examine here the influence of cholesterol esters of varying unsaturation on fully hydrated egg phosphatidylethanolamine systems, which un...

Wax esters are major constituents of the surface lipids in many terrestrial arthropods, but their study is complicated by their diversity. We developed a procedure for quantifying isomers in mixtures of straight-chain saturated and unsaturated wax esters having the same molecular weights, using single-ion monitoring of the total ion current data from gas chromatography-mass spectrometry. We exa...