The purpose of this retrospective study was to investigate the value of minimally invasive esophagectomy (combined thoracoscopic-laparoscopic esophagectomy) for esophageal squamous cell carcinoma in elderly patients (≥70 years). From January 2009 to December 2014, 58 consecutive patients aged older than 70 years with clinical stage stage I or II esophageal squamous cell carcinoma underwent mini...

Cyclo-oxygenase (COX)-2 is not usually detectable in normal tissues but is induced in inflammation and carcinogenesis. The level of COX-2 is elevated in cancer tissues of the colon, bladder, and skin. In the esophagus, squamous cell carcinoma and adenocarcinoma are known to express COX-2. The purpose of this study was to clarify the association of COX-2 expression with clinicopathological facto...

The use of nonsteroidal anti-inflammatory drugs is associated with a lower risk for esophageal squamous cell carcinoma, in which overexpression of cyclooxygenase-2 (COX-2) is frequently reported. Prostaglandin E(2) (PGE(2)), a COX-2-derived eicosanoid, is implicated in the promotion of cancer growth. However, the precise role of PGE(2) in the disease development of esophageal squamous cell carc...

Esophageal cancer is a prominent worldwide illness that divided into two main subtypes: esophageal squamous cell carcinoma and adenocarcinoma. Mortality rates are alarming, the understanding of mechanisms involved in development, becomes essential. Purinergic signaling related to many diseases among these various types tumors. Here we studied effects P2Y2 receptor activation different cancer. t...

abstract carcinoma of the vulva has commonly been recognized as a disease of postmenopausal women, but some cases have been reported in young women during pregnancy. medical records were reviewed for a patient with vulvar carcinoma diagnosed in pregnancy. using medline and cross references, pertinent articles were sought and reviewed. a 28-year-old afghan woman in her sixth pregnancy presented ...

OBJECTIVE Overexpression of cyclase-associated proteins has been associated with poor prognosis in several human cancers. Cyclase-associated protein 1 is a member of the cyclase-associated proteins which contributes to tumor progression. The aim of the present study was to examine the expression of cyclase-associated protein 1 and to elucidate its clinicopathologic significance in a larger serie...

Preinvasive lesions of squamous cell carcinoma are well defined morphologically and provide a model for multistage carcinogenesis. Since alterations in the p53 tumor suppressor gene occur frequently in invasive esophageal squamous cell carcinoma, we examined a set of preinvasive lesions to investigate the timing of p53 mutation. Surgically resected tissues from nine patients with esophageal squ...

Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, which are essential for cell proliferation. The purpose of this study was to evaluate ODC expression in human esophageal cancer at the mRNA level. Sixty-four pairs of primary esophageal cancers and normal esophageal epithelia were examined by reverse transcription-PCR for ODC mRNA expression. The ODC mRNA levels we...

PURPOSE The RAS association domain family 1A (RASSF1A) gene, a candidate tumor suppressor gene, is frequently inactivated by hypermethylation of its promoter region in several human cancers. The aim of this study was to evaluate the promoter methylation status of the RASSF1A in esophageal squamous cell carcinoma. EXPERIMENTAL DESIGN We analyzed the methylation status of RASSF1A promoter by me...