compounds were /V-acetylcysteine, bismuththiol. calcium glucarate, (±) catechin, diallyl disulfide, glycaric acid, i>-glucaro-l,4-lactone. \-(4hydro\yphenyl)retinamide, n-limonene, mesna, retinole acid, rutin, quercetin, silymarin, and taurine. In examining the nature of compounds that inhibited rat trachea! epithelial cell transformation, several possible chemoprevcntivc mechanisms appeared t...

Mutations in leucine-rich repeat kinase-2 are the most common cause of familial Parkinson's disease. The prevalent G2019S mutation increase oxidative, kinase and toxic activity and inhibit endogenous peroxidases. We initially screened a library of 84 antioxidants and identified seven phenolic compounds that inhibited kinase activity on leucine-rich repeat kinase-2 substrates. The representative...

Cichorium intybus L. (Asteraceae) is one of the most widely used medicinal plants globally. The plant species great economic interest due to its high content secondary metabolites. present study was performed compare GC/MS-based metabolic profiles and total phenolic micropropagated wild-growing plants. An optimized protocol for in vitro multiplication C. using stem segments from raised seedling...

6,7-Dihydroxycoumarin (6,7-HC) (aesculetin) is a natural and synthetic coumarin derivative of great interest for use by humans due to their potent antioxidant properties. Considering that there are no reports that assess the in vivo genetic toxicity of 6,7-HC, the aim of the present study was to investigate its genotoxic potential in terms of DNA damage in peripheral blood, liver, bone marrow a...

AIM To observe the biotransformation process of a Chinese compound, aesculin, by human gut bacteria, and to identify its metabolites in rat urine. METHODS Representative human gut bacteria were collected from 20 healthy volunteers, and then utilized in vitro to biotransform aesculin under anaerobic conditions. At 0, 2, 4, 8, 12, 16, 24, 48 and 72 h post-incubation, 10 mL of culture medium was...