(Letter to the Editor) SIR, We read with great interest the report by Coleiro et al. [1] describing a pilot study on the tolerability and efficiency of fluoxetine for the treatment of Raynaud's phenomenon. This study confirmed previous case reports suggesting the usefulness of selective serotonin reuptake inhibitors (SSRIs) in the management of Raynaud's phenomenon [2, 3]. Here we describe for ...

because tuberculosis may be suspected and investigated more readily among men or black or Asian people. Our study was limited by the amount of missing surveillance data. It was also impossible to determine the relative contribution of patient and healthcare provider to the total delay. Potential confounders—for example, coinfection with HIV or the accuracy of the data among patients whose first...

The main purpose of this paper is to study a pair of optimization problems on differentiable manifolds under (p, r)-invexity assumptions. By using the (p, r)-invexity assumptions on the functions involved, optimality conditions and duality results (Mond-Weir, Wolfe and mixed type) are established on differentiable manifolds. We construct counterexample to justify that our investigations are mor...

A painful syndrome characterized by pain, heat and redness of the extremities has received at least two different names: erythromelalgia and erythermalgia. The term 'erythromelalgia', which is derived from the 3 Greek words erythros (red), melon (extremities) and algos (pain) was first proposed by Mitchell in 1878 [15] to indicate red, painful extremities. Mitchell was not entirely certain abou...

Vascular disease of the upper extremity consists of a diverse group of conditions of different etiologies and presentations. These conditions can be broken down into the following groups: (a) vaso-occlusive disease, which consists of embolism, thrombosis, aneurysms, atherosclerosis, and vasculitis; (b) vasospastic conditions, including Raynaud’s disease, secondary Raynaud’s phenomenon, acrocyan...

In this paper, we discuss nondifferentiable minimax fractional programming problem where the involved functions are locally Lipschitz. Furthermore, weak, strong and strict converse duality theorems are proved in the setting of Mond-Weir type dual under the assumption of generalized (F,α,ρ,d)-convexity.