Mammalian genomes typically contain hundreds of thousands of endogenous retroviruses (ERVs), derived from ancient retroviral infections. Using this molecular 'fossil' record, we reconstructed the natural history of a specific retrovirus lineage (ERV-Fc) that disseminated widely between ~33 and ~15 million years ago, corresponding to the Oligocene and early Miocene epochs. Intercontinental viral...

Endogenous retrovirus (ERV) genomes integrated into the chromosomal DNA of the host were first detected in chickens and mice as Mendelian determinants of Gag and Env proteins and of the release of infectious virus particles. The presence of ERV was confirmed by DNA hybridization. With complete host genomes available for analysis, we can now see the great extent of viral invasion into the genome...

Endogenous retroviruses (ERVs) are abundant in mammalian genomes and contain sequences modulating transcription. The impact of ERV propagation on the evolution of gene regulation remains poorly understood. We found that ERVs have shaped the evolution of a transcriptional network underlying the interferon (IFN) response, a major branch of innate immunity, and that lineage-specific ERVs have disp...

8. CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. ABSTRACT 9 Endogenous retroviruses (ERVs) arise from retroviruses chromosomally integrated in 1 0 the host germline. ERVs are common in vertebrate genomes and provide a valuable 1 1 fossil record of past retroviral infections to invest...

Humans share about 99% of their genomic DNA with chimpanzees and bonobos; thus, the differences between these species are unlikely to be in gene content but could be caused by inherited changes in regulatory systems. Endogenous retroviruses (ERVs) comprise approximately 5% of the human genome. The LTRs of ERVs contain many regulatory sequences, such as promoters, enhancers, polyadenylation sign...

A recurring problem in conceptual modelling and ontology development is the representation of part-whole relations, with a requirement to be able to distinguish between essential and mandatory parts. To solve this problem, we formally characterize the semantics of these shareability notions by resorting to the temporal conceptual model ERV T and its formalization in the description logic DLRUS .

Abstract The female reproductive tract (FRT) is a unique barrier site. It tolerates foreign entities like sperm and the fetus for reproduction but must also be immunologically active enough to control pathogens, viruses. Millions of women use antibiotics or anti-retrovirals, these treatments alter environment FRT by changing microbiota inhibiting endogenous retroviruses, impact this on immunity...

The work presented in this thesis focuses on reducing the energy demand of a residential building by using a coupled ground-source heat pump/energy recovery ventilation (GSHP-ERV) system to present a novel approach to space condition and domestic hot water supply for a residence. The proposed system is capable of providing hot water on-demand with a high coefficient of performance (COP), thus e...