[1] Cross-well electrical resistivity tomography (ERT) was used to monitor the migration of a saline tracer in a two-well pumping-injection experiment conducted at the Massachusetts Military Reservation in Cape Cod,Massachusetts. After injecting 2200mg/L of sodium chloride for 9 hours, ERT data sets were collected from four wells every 6 hours for 20 days. More than 180,000 resistance measureme...

The efficient introduction of somatic mutations in a given gene, at a given time, in a specific cell type will facilitate studies of gene function and the generation of animal models for human diseases. We have shown previously that conditional recombination-excision between two loxP sites can be achieved in mice by using the Cre recombinase fused to a mutated ligand binding domain of the human...

Pompe disease results from acid α-glucosidase (GAA) deficiency, and enzyme replacement therapy (ERT) with recombinant human (rh) GAA has clinical benefits, although its limitations include the short half-life of GAA and the formation of antibody responses. The present study compared the efficacy of ERT against gene transfer with an adeno-associated viral (AAV) vector containing a liver-specific...

We aimed to establish the profile of Irish patients with Hunter Syndrome (Mucopolysaccharidosis type II, MPS II) receiving weekly intravenous Enzyme Replacement Therapy (ERT) with recombinant iduronate-2-sulfatase and to assess the social impact and parental opinion of ERT through the use of a parental questionnaire. Nine patients aged 3.5- 14 years have received a mean of 2 (range 0.5-3.5) yea...

Two important mechanisms affect our ability to estimate solute concentrations quantitatively from the inversion of field-scale electrical resistivity tomography ERT data: 1 the spatially variable physical processes that govern the flow of current as well as the variation of physical properties in space and 2 the overparameterization of inverse models, which requires the imposition of a smoothin...

BACKGROUND Fabry disease is an X linked lysosomal storage disease caused by deficiency of the lysosomal enzyme alpha-galactosidase A. This leads to accumulation of globotriaosylceramide in nearly all tissues, including the blood vessels, kidney, myocardium, and nervous system. Symptoms often begin in childhood and include acroparaesthesia, with burning or tingling pain that spreads from the ext...

Regardless of age, race, and ethnicity, cardiovascular disease is the number 1 cause of death for women, and its prevalence rises rapidly after menopause.1–4 This postmenopausal increase is believed to result from the loss of endogenous estrogen. Although estrogen replacement therapy (ERT) has long been thought to protect against menopauseassociated cardiovascular anomalies, osteoporosis, hot f...

We propose in this work a fast numerical algorithm for solving the equation of radiative transfer (ERT) in isotropic media. The algorithm has two steps. In the first step, we derive an integral equation for the angularly averaged ERT solution by taking advantage of the isotropy of the scattering kernel, and solve the integral equation with a fast multipole method (FMM). In the second step, we s...

Regardless of age, race, and ethnicity, cardiovascular disease is the number 1 cause of death for women, and its prevalence rises rapidly after menopause.1–4 This postmenopausal increase is believed to result from the loss of endogenous estrogen. Although estrogen replacement therapy (ERT) has long been thought to protect against menopauseassociated cardiovascular anomalies, osteoporosis, hot f...

BACKGROUND The aim of the present study was to assess manifestations of and applied treatment concepts for females with Fabry disease (FD) according to the current European Fabry Guidelines. METHODS Between 10/2008 and 12/2014, data from the most recent visit of 261 adult female FD patients from six German Fabry centers were retrospectively analyzed. Clinical presentation and laboratory data,...