نتایج جستجو برای: erg gene expression
تعداد نتایج: 1609450 فیلتر نتایج به سال:
High levels of BAALC, ERG, EVI1 and MN1 expression have been associated with shorter overall survival in AML but standardized and clinically validated assays are lacking. We have therefore developed and optimized an assay for standardized detection of these prognostic genes for patients with intermediate cytogenetic risk AML. In a training set of 147 intermediate cytogenetic risk cases we perfo...
چکیده ندارد.
objective(s): streptococcus pyogenes produces extracellular hyaluronidase enzyme. this enzyme is directly associated with the spread of the organism during infection. the objective of the present study was to clone and express the nucleotide sequence of the enzyme which is involved in hyaluronidase enzymatic activity. materials and methods: the enzymatic region of hyaluronidase gene was detecte...
antimicrobial peptide brevinin-2r induces the secretion of a pro-inflammatory cytokine in hepg2 cells
introduction: antimicrobial peptides as the body's defense strategy play an important role in resistance against infection of microorganism. these peptides are able to modulate the immune and inflammatory processes through the production of defensive molecules. therefore, the modulatory effects of brevinin-2r, an antimicrobial peptide extracted from the skin of the frog (rana ridibunda), w...
Prostate cancer is the most common non-dermatologic malignancy in men in the Western world. Recently, a frequent chromosomal aberration fusing androgen regulated TMPRSS2 promoter and the ERG gene (TMPRSS2/ERG) was discovered in prostate cancer. Several studies demonstrated cooperation between TMPRSS2/ERG and other defective pathways in cancer progression. However, the unveiling of more specific...
The EWS-ERG fusion protein is found in human sarcomas with the chromosomal translocation t(21;22)(q22;q12), where the translocation is considered to be an initiating event in sarcoma formation within uncommitted mesenchymal cells, probably long-lived progenitors capable of self renewal. The fusion protein may not therefore have an oncogenic capability beyond these progenitors. To assess whether...
Expression of the ERG proto-oncogene, is activated in 50-70% of prostate tumors by androgen receptor (AR) mediated signals due to the fusion of AR regulated promoters (primarily TMPRSS2 and to a lesser extent SLC45A3 and NDRG1) to the ERG protein coding sequence. Our previous studies of quantitative expression levels of ERG or TMPRSS2-ERG fusion transcripts have noted that relatively low or no ...
Children with Down syndrome develop a unique congenital clonal megakaryocytic proliferation disorder (transient myeloproliferative disorder [TMD]). It is caused by an expansion of fetal megakaryocyte-erythroid progenitors (MEPs) triggered by trisomy of chromosome 21 and is further enhanced by the somatic acquisition of a mutation in GATA1. These mutations result in the expression of a short-iso...
ژن tlr4 بر روی کروموزوم 17 قرار گرفته و دارای 3 اگزون و 2 اینترون است. این ژن باعث سنتز پروتئینی با تعداد843 اسید آمینه می شود که تنظیم و شروع کننده یپاسخ های ایمنی به هنگام آلودگی با باکتری های گرم منفی است. هدف از این مطالعه تجزیه و تحلیل ساختاری ژن tlr4 و ارتباط آن با صفات ایمنی در دو سویه بومی و تجاری بود. برخی از صفات ایمنی مثل میزان عیار پادتن های تولید شده علیه srbc (عیار پادتن کل، ta؛ ع...
background: ovarian tissue cryopreservation is an alternative strategy to preserve the fertility of women predicted to undergo premature ovarian failure. this study was designed to evaluate the expression of folliculogenesis-related genes, including factor in the germline alpha (figla), growth differentiation factor-9 (gdf-9), follicle-stimulating hormone receptor (fshr), and kit ligand after v...
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