نتایج جستجو برای: epithelial ovarian cancer

تعداد نتایج: 1064060  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
J B Welsh P P Zarrinkar L M Sapinoso S G Kern C A Behling B J Monk D J Lockhart R A Burger G M Hampton

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in part because of the lack of effective early detection methods. Although alterations of several genes, such as c-erb-B2, c-myc, and p53, have been identified in a significant fraction of ovarian cancers, none of these mutations are diagnostic of malignancy or predictive of tumor behavior over time. Here, we used ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Rebecca T Marquez Keith A Baggerly Andrea P Patterson Jinsong Liu Russell Broaddus Michael Frumovitz Edward N Atkinson David I Smith Lynn Hartmann David Fishman Andrew Berchuck Regina Whitaker David M Gershenson Gordon B Mills Robert C Bast Karen H Lu

PURPOSE Epithelial ovarian cancers are thought to arise from flattened epithelial cells that cover the ovarian surface or that line inclusion cysts. During malignant transformation, different histotypes arise that resemble epithelial cells from normal fallopian tube, endometrium, and intestine. This study compares gene expression in serous, endometrioid, clear cell, and mucinous ovarian cancers...

Ahmadieh MH Bahador Zadeh M Davar R Ghodrati Pour Z, Khalili Maybodi M Moghimi M

Background: Ovarian cancer is the fifth most common cancer in woman and the fifth most frequent cause of cancer death. Ovarian cancers are usually asymptomatic until metastasized, patients have advanced disease at diagnosis in more than 2/3 of the cases. Totally 75-80 % of ovarian masses are benign. The strongest patient related risk factor for ovarian cancer is increasing age. The most ovarian...

Journal: :International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2013
Andy H Lee Maria Pasalich Dada Su Li Tang Van Dinh Tran Colin W Binns

OBJECTIVE This study aimed to investigate the association between mushroom consumption and risk of epithelial ovarian cancer in southern Chinese women. METHODS A hospital-based case-control study was undertaken in Guangzhou, Guangdong Province, from 2006 to 2008. Participants were 500 incident patients with epithelial ovarian cancer and 500 controls, with a mean (SD) age of 59 (6) years. Info...

2017
Xiu-Jie Yu Jian-Chan Song Jing Du Yi-Quan Shi Yi-Xin Liu Yan Shen

Objective: Hypoxia plays an important role in tumorigenesis and tumor progression. Under the hypoxia environment, glucose uptake is increased to support the growth of tumor. Here we analyzed the expression of GLUT-1 and hypoxia inducible factor-1α (HIF-1α) in epithelial ovarian tumors, investigated the correlation between their expression and the molecular typing (Kurman’s model) or histologica...

Journal: :middle east journal of cancer 0
fatemeh sari aslani department of pathology, shiraz university of medical sciences, shiraz, iran azarmidokht momeni department of pathology, shiraz university of medical sciences, shiraz, iran mozhdeh momtahan department of obstetrics and gynecology, shiraz university of medical sciences, shiraz, iran mozhgan akbarzadeh jahromi department of pathology, shiraz university of medical sciences, shiraz, iran amir reza dehghanian department of pathology, shiraz university of medical sciences, shiraz, iran dorna motevali department of pathology, shiraz university of medical sciences, shiraz, iran

background: ovarian cancer comprises a heterogeneous group of neoplasms. the prognosis cannot be predicted by histopathologic examination alone. the aim of this study is to evaluate p53, pten, and β-catenin expressions in primary ovarian carcinomas in an attempt to find a possible relationship with morphologic parameters and clinical findings. methods: the study included 100 epithelial ovarian ...

Journal: :Carcinogenesis 2013
Pengnan Zhang Pengfei Zhang Min Zhou Hua Jiang Haiyan Zhang Bizhi Shi Xiaorong Pan Huiping Gao Hong Sun Zonghai Li

Recently, de4 EGFR, a variant of epidermal growth factor receptor (EGFR) with exon 4 deletion, was identified in glioblastoma and ovarian cancer. However, its biological function on ovarian cancer is still not clear. In this study, the expression profile of de4 EGFR and its contribution to epithelial ovarian cancer cells proliferation, invasiveness and drug resistance were studied. Our results ...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004
Elizabeth R Smith Mary B Daly Xiang-Xi Xu

Epidemiological and experimental data support the use of nonsteroidal anti-inflammatory drugs, including specific inhibitors of cyclooxygenase 2 (Cox-2), as chemopreventive agents in a number of epithelial cancers, including colon, mammary, esophageal, lung, and oral cavity (1). There is also evidence to suggest that nonsteroidal anti-inflammatory drugs may be chemopreventive against ovarian ca...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Delia Mezzanzanica Marina Fabbi Marina Bagnoli Samantha Staurengo Marco Losa Emanuela Balladore Paola Alberti Lara Lusa Antonino Ditto Silvano Ferrini Marco A Pierotti Mattia Barbareschi Silvana Pilotti Silvana Canevari

PURPOSE Currently available clinicopathologic prognostic factors are imperfect predictors of clinical course in advanced-stage epithelial ovarian cancer patients. New molecular predictors are needed to identify patients with higher risk of relapse or death from disease. In a retrospective study, we investigated the prognostic impact of activated leukocyte cell adhesion molecule (ALCAM) expressi...

Journal: :PLoS ONE 2009
Mandi M. Murph Wenbin Liu Shuangxing Yu Yiling Lu Hassan Hall Bryan T. Hennessy John Lahad Marci Schaner Åslaug Helland Gunnar Kristensen Anne-Lise Børresen-Dale Gordon B. Mills

BACKGROUND Lysophosphatidic acid (LPA) governs a number of physiologic and pathophysiological processes. Malignant ascites fluid is rich in LPA, and LPA receptors are aberrantly expressed by ovarian cancer cells, implicating LPA in the initiation and progression of ovarian cancer. However, there is an absence of systematic data critically analyzing the transcriptional changes induced by LPA in ...

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