نتایج جستجو برای: epithelial ovarian cancer
تعداد نتایج: 1064060 فیلتر نتایج به سال:
Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in part because of the lack of effective early detection methods. Although alterations of several genes, such as c-erb-B2, c-myc, and p53, have been identified in a significant fraction of ovarian cancers, none of these mutations are diagnostic of malignancy or predictive of tumor behavior over time. Here, we used ...
PURPOSE Epithelial ovarian cancers are thought to arise from flattened epithelial cells that cover the ovarian surface or that line inclusion cysts. During malignant transformation, different histotypes arise that resemble epithelial cells from normal fallopian tube, endometrium, and intestine. This study compares gene expression in serous, endometrioid, clear cell, and mucinous ovarian cancers...
Background: Ovarian cancer is the fifth most common cancer in woman and the fifth most frequent cause of cancer death. Ovarian cancers are usually asymptomatic until metastasized, patients have advanced disease at diagnosis in more than 2/3 of the cases. Totally 75-80 % of ovarian masses are benign. The strongest patient related risk factor for ovarian cancer is increasing age. The most ovarian...
OBJECTIVE This study aimed to investigate the association between mushroom consumption and risk of epithelial ovarian cancer in southern Chinese women. METHODS A hospital-based case-control study was undertaken in Guangzhou, Guangdong Province, from 2006 to 2008. Participants were 500 incident patients with epithelial ovarian cancer and 500 controls, with a mean (SD) age of 59 (6) years. Info...
Objective: Hypoxia plays an important role in tumorigenesis and tumor progression. Under the hypoxia environment, glucose uptake is increased to support the growth of tumor. Here we analyzed the expression of GLUT-1 and hypoxia inducible factor-1α (HIF-1α) in epithelial ovarian tumors, investigated the correlation between their expression and the molecular typing (Kurman’s model) or histologica...
background: ovarian cancer comprises a heterogeneous group of neoplasms. the prognosis cannot be predicted by histopathologic examination alone. the aim of this study is to evaluate p53, pten, and β-catenin expressions in primary ovarian carcinomas in an attempt to find a possible relationship with morphologic parameters and clinical findings. methods: the study included 100 epithelial ovarian ...
Recently, de4 EGFR, a variant of epidermal growth factor receptor (EGFR) with exon 4 deletion, was identified in glioblastoma and ovarian cancer. However, its biological function on ovarian cancer is still not clear. In this study, the expression profile of de4 EGFR and its contribution to epithelial ovarian cancer cells proliferation, invasiveness and drug resistance were studied. Our results ...
A mechanism for cox-2 inhibitor anti-inflammatory activity in chemoprevention of epithelial cancers.
Epidemiological and experimental data support the use of nonsteroidal anti-inflammatory drugs, including specific inhibitors of cyclooxygenase 2 (Cox-2), as chemopreventive agents in a number of epithelial cancers, including colon, mammary, esophageal, lung, and oral cavity (1). There is also evidence to suggest that nonsteroidal anti-inflammatory drugs may be chemopreventive against ovarian ca...
PURPOSE Currently available clinicopathologic prognostic factors are imperfect predictors of clinical course in advanced-stage epithelial ovarian cancer patients. New molecular predictors are needed to identify patients with higher risk of relapse or death from disease. In a retrospective study, we investigated the prognostic impact of activated leukocyte cell adhesion molecule (ALCAM) expressi...
BACKGROUND Lysophosphatidic acid (LPA) governs a number of physiologic and pathophysiological processes. Malignant ascites fluid is rich in LPA, and LPA receptors are aberrantly expressed by ovarian cancer cells, implicating LPA in the initiation and progression of ovarian cancer. However, there is an absence of systematic data critically analyzing the transcriptional changes induced by LPA in ...
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