Epithelial-to-mesenchymal transition (EM transition) is a process wherein epithelial cells lose their intrinsic characteristics and cell–cell junctions differentiate into mesenchymal phenotype. EM an important feature of cancer invasion metastasis. In this study, we aimed to investigate the inhibitory effect gintonin (GT), ingredient ginseng, on using A549 cells. The proliferation was enhanced ...

klossiella muris is ordinarily nonpathogenic, although in heavy infections the kidneys may have minute grayish necrotic foci over their entire surface and the epithelium of the infected kidney tubules may be destroyed. for histopathological diagnosis of klossiella muris infection, kidneys of 24 mice were studied that klossiella in various stages of development were observed in the renal tubules...

Epithelial tissue is a type that mainly covers the surfaces of body and organs. Most epithelial tissues are composed highly proliferative cells, necessitating robust stem cell activity. also most common site cancers. Therefore, identifying cells their self-renewal mechanisms prerequisite for promoting homeostasis, understanding cancer pathogenesis, developing regenerative therapy prevention. Ov...

Lichen planus (LP) is a chronic inflammatory disease of probable immune-based etiology. The pathogenesis of LP is unclear, but apoptotic changes in epidermal (epithelial) cells have been reported. Destruction of the basal cell layer is observed and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium. The aim of this study was to evaluate and co...

understanding the molecular mechanisms in regeneration could help the stem cell therapists to improve the clinical practices and could be considered a major milestone in the translation of stem cell research to clinics. chemokines have been described as one of the most significant singling networks in stem cells homing and regeneration of damaged organs. cxcr4/cxcl12 has been known as a key pla...

The paper discusses diverse aspects of the concept epithelial-mesenchymal transition and compares basics this with classical concepts tissue biology. idea was first suggested by Elizabeth Hay (1927–2007) in 1968 based on analysis tridermogenesis development growth avian embryo. In late 80 s – early 90 twentieth century, epithelial–mesenchymal won supporters-pathomorphologists our country who ap...