Electroencephalographic source localization (ESL) by noninvasive means is an area of renewed interest in clinical epileptology. This has been driven by innovations in the computer-assisted modeling of dipolar and distributed sources for the investigation of focal epilepsy; a process fueled by the ever-increasing computational power available to researchers for the analysis of scalp EEG recordin...

It is surprising that the piriform cortex, when compared to the hippocampus, has been given relatively little significance in human epilepsy. Like the hippocampus, it has a phylogenetically preserved three-layered cortex that is vulnerable to excitotoxic injury, has broad connections to both limbic and cortical areas, and is highly epileptogenic - being critical to the kindling process. The wel...

EEG (Electroencephalogram) is a technique for identifying neurological disorders. There are various neurological disorders like Epilepsy, brain cancer, etc. Feature extraction and classification of electroencephalogram (EEGs) signals for (normal and epileptic) is a challenge for engineers and scientists. Various signal processing techniques have already been proposed for classification of non-l...

One of the factors which directly affects quality of life (QOL) in patients with epilepsy is society’s attitude toward this disease. Despite considerable progress in the treatment of epilepsy, many patients continue to experience extremely prejudiced behavior from society, even in culturally and economically developed countries. The climate accompanying epilepsy is still replete with prejudice,...

Many studies have focused on the nonlinear analysis of electroencephalography mainly for the characterization of epileptic brain states. The spatial and temporal dynamics of the epileptogenic process is still not clear completely especially the most challenging aspects of epileptology which is the anticipation of the seizure. Despite all the efforts we still don’t know how and when and why the ...

Bilateral synchronous epileptiform discharges registered in patients with partial epilepsies may be generated by different pathophysiological mechanisms. Differentiation between underlying mechanisms is often crucial for correct diagnosis and adequate treatment in clinical epileptology. The aim of this study was to model in rats two possible mechanisms--secondary bilateral sychrony and interact...

We reviewed computer models that have been developed to reproduce and explain epileptiform activity. Unlike other already-published reviews on computer models of epilepsy, the proposed overview starts from the various types of epileptiform activity encountered during both interictal and ictal periods. Computational models proposed so far in the context of partial and generalized epilepsies are ...

PURPOSE Some enigmatic remarks and behaviors of Socrates have been a subject of debate among scholars. We investigated the possibility of underlying epilepsy in Socrates by analyzing pathographic evidence in ancient literature from the viewpoint of the current understanding of seizure semiology. METHODS We performed a case study from a literature survey. RESULTS In 399 BCE, Socrates was tri...

Localization of the epileptogenic zone (EZ) is an important issue in epileptology, even though there is not a unique definition of the epileptic focus. By using complex network analysis of electrocorticographic (ECoG) data we identify three singular areas in the temporal lobe of epileptic patients, the node with highest local synchronization power, the most connected node, and the node with hig...

Welcome to this section of Seizure, which will appear in each issue from now, and is dedicated to continuing professional development (CPD) and continuing medical education (CME). Our aim is to cover the subject matter of epileptology in a comprehensive series of updates over a three year period, using a ‘topic teaching’ approach. A specially commissioned review article will introduce each topi...