Dihydrofolate reductase (DHFR) is the subject of intensive investigation since it appears to be the primary target enzyme for antifolate drugs. Fluorescence quenching experiments show that the ester bond-containing tea polyphenols (-)-epigallocatechin gallate (EGCG) and (-)-epicatechin gallate (ECG) are potent inhibitors of DHFR with dissociation constants (K(D))of 0.9 and 1.8 microM, respectiv...

BACKGROUND Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation for treatment of skin during radiotherapy exists. In this study, we explored the effect of topically-applied tea extracts on the duration of radiation-induced skin toxicity. We in...

In article number 2009442, Ang Li, Yilong Cheng, and co-workers develop a facile dressing strategy via one-pot radical copolymerization of acrylamide the complex formed through boronate ester bond by 3-acrylamido phenylboronic acid green tea derivative epigallocatechin-3-gallate. The resulting hydrogels exhibit good mechanical strength, adequate tissue adhesiveness, fast self-healing capability...

About 600 species of Passiflora are described around the world, which 120 native to Brazil. In present work, phytochemical compounds were analyzed by high-performance liquid chromatography, and antioxidant activities (AOX) measured in pulp P. edulis cincinnata species. The presented a higher bioactive content AOX when compared cincinnata. Citric malic acids main organic found. principal compone...