Plant organ growth is controlled by inter-cell-layer communication, which thus determines the overall size of the organism. The epidermal layer interfaces with the environment and participates in both driving and restricting growth via inter-cell-layer communication. However, it remains unknown whether the epidermis can send signals to internal tissue to limit cell proliferation in determinate ...

BACKGROUNDS Basal cell carcinoma affects areas of the body that have been exposed to the sun, and this disorder has different clinical and histopathologic presentations. Some of these forms have a higher potential of local aggressiveness, while others have a lower potential. Langerhans cells actively participate in the skin immune system. OBJECTIVES To quantitatively evaluate the number of Lang...

In 1978 Sun and Green carried out a densitometry-based analysis of polyacrylamide gelelectrophoresed samples and reported that keratin proteins account for 25~35% of total cellular proteins in human epidermal keratinocytes serially passaged in primary culture. This represents an astounding figure with very significant implications for the structural support role of keratin intermediate filament...

Dermatologic disease, although seldom life threatening, can be extremely disfiguring and interfere with the quality of life. In addition, as opposed to other organs, just the aging of skin and its adnexal structure the hair follicle can result in cosmetic concerns that affect most of us. The articles in this dermatology Review Series demonstrate recent progress in understanding the cell biology...

In the mammalian skin epidermis, it has long been unclear how molecularly heterogenous stem/progenitor cell populations fit into complete trajectory of epidermal differentiation. Here, we combine in vivo imaging with single-cell RNA sequencing to define early stages stem differentiation at molecular and behavioral level. We show that differentiation, from commitment exit layer, is a multi-day p...

In vascular plants the shoot apical meristem consists of three tissue layers, L1, L2 and the L3, that are kept separate during organ formation and give rise to the epidermis (L1) and the subepidermal tissues (L2, L3). For proper organ development these different tissue layers must interact with each other, though their relative contributions are a matter of debate. Here we use ANGUSTIFOLIA (AN)...

Epidermis is one of the best-studied tissues in mammals that contain types of stem cells. Outstanding works in recent years have shed great light on behaviors of different epidermal stem cell populations in the homeostasis and regeneration of the epidermis as well as hair follicles. Also, the molecular mechanisms governing these stem cells are being elucidated, from genetic to epigenetic levels...

Local relapses of psoriasis involve educated T cells with the capacity to survive in skin. Inherited from previous flares, tissue-resident memory are prone produce IL-17 resolved epidermis. Their intake fatty acids through FABP5 receptor is essential for their residence and function, we thus hypothesize that surface composition could affect epidermal cell populations. In patients successfully t...

Skin aging is a complex biological process leading to multiple functional defects in the different structure of skin tissues. Epidermal especially characterized by an alteration tissue renewal associated impairment keratinocytes differentiation process. We have previously reported that microRNA miR-30a over-expressed aged epidermis and we shown organotypic models this induction impairs epiderma...

A position-dependent pattern of epidermal cell types is produced during root development in Arabidopsis thaliana. This pattern is reflected in the expression pattern of GLABRA2 (GL2), a homeobox gene that regulates cell differentiation in the root epidermis. GL2 promoter::GUS fusions were used to show that the TTG gene, a regulator of root epidermis development, is necessary for maximal GL2 act...