Circulating endothelial progenitor cells (EPC) contribute to endothelial replenishment. Telmisartan is an angiotensin-receptor blocker with PPARgamma-agonistic properties. PPARgamma-agonists and HMG-CoA reductase inhibitors have been shown to enhance EPC number and function. We focused on the effects of telmisartan alone or in combination with simvastatin on EPC. EPC were isolated from healthy ...

Introduction Computers these days are no longer just placed on desktops in the form of stationary machines, they are also embedded into everyday objects. The seamless integration of computing capabilities within physical objects is the foundation for an Internet of Things, which interlinks the physical world of goods and items with the virtual world of services and data bases. The most prominen...

Aging is associated with an increased risk for atherosclerosis. A possible cause is low numbers and dysfunction of endothelial progenitor cells (EPC) which insufficiently repair damaged vascular walls. We hypothesized that decreased levels of insulin-like growth factor-1 (IGF-1) during age contribute to dysfunctional EPC. We measured the effect of growth hormone (GH), which increases endogenous...

Probabilistic ecological risk assessment (PERA) for deriving ecological protective concentration (EPC) was previously suggested in USA, Australia, New Zealand, Canada, and Netherland. This study suggested the EPC of cadmium (Cd) based on the PERA to be suitable to Korean aquatic ecosystem. First, we collected reliable ecotoxicity data from reliable data without restriction and reliable data wit...

BACKGROUND DNA barcoding is a popular tool in taxonomic and phylogenetic studies, but for most animal lineages protocols for obtaining the barcoding sequences--mitochondrial cytochrome C oxidase subunit I (cox1 AKA CO1)--are not standardized. Our aim was to explore an optimal strategy for arachnids, focusing on the species-richest lineage, spiders by (1) improving an automated DNA extraction pr...

AIMS Hyperaldosteronism is associated with vascular injury and increased cardiovascular events. Bone marrow-derived endothelial progenitor cells (EPCs) play an important role in endothelial repair and vascular homeostasis. We hypothesized that hyperaldosteronism impairs EPC function and vascularization capacity in mice and humans. METHODS AND RESULTS We characterized the effects of aldosteron...

Disorazoles are macrocyclic polyketides first isolated from the fermentation broth of the myxobacterium Sorangium cellulosum. Both the major fermentation product disorazole A1 and its much rarer companion disorazole C1 exhibit potent cytotoxic activity against many human tumor cells. Furthermore, the disorazoles appear to bind tubulin uniquely among known antimitotic agents, promoting apoptosis...

JANSEN, B. C. The toxic antigenic factors produced by Clostridium botulinum types C and D. Onderstepoort ]. vet Res., 38 (2), 93-98 (1971). The toxic factors produced by Clostridium botulinum (Van Ermengem, 1896), types C and D were determined. Monospecific antisera were prepared against the different factors. It was shown that type Coc produces factors C" C2 and D; type C f3 produces factor C ...

We present WISP, a wireless, battery-free platform for sensing and computation that is powered and read by a standards compliant Ultra-High Frequency (UHF) RFID reader. To the reader, the WISP appears to be an ordinary RFID tag. The WISP platform includes a general-purpose programmable flash microcontroller and implements the bi-directional communication primitives required by the Electronic Pr...