PGE(2) is a potent stimulator of renin release. So far, the contribution of each of the four PGE(2) receptor subtypes (EP(1)-EP(4)) in the regulation of renin release has not been characterized. Therefore, we investigated the effects PGE(2) on renin secretion rates (RSR) from isolated, perfused kidneys of EP(1)-/-, EP(2)-/-, EP(3)-/-, EP(4)-/-, and wild-type mice. PGE(2) concentration dependent...

Background: Recent advances showed that oxygen radicals and hydrogen peroxides are linked with the development of several pathological processes associated with chemotherapy, including adverse effects of anti-tumor drugs. Methotrexate (MTX) is an antifolate that is widely used in the treatment of rheumatic disorders and malignant tumors. The efficacy of methotrexate is often limited by severe s...

We review some of the recent experimental results obtained at high-energy colliders with emphasis on LEP and SLC results.

there are many different ways to subdivide the spectrum of a bounded linear operator; some of them aremotivated by applications to physics (in particular, quantum mechanics). in this study, the relationship betweenthe subdivisions of spectrum which are not required to be disjoint and goldberg's classification are given.moreover, these subdivisions for some summability methods are studied.

The present study was designed to investigate the central nervous system activity of 23 novel phenylpiperazine pyrrolidin-2-one derivatives. These compounds had marked antiarrhythmic and hypotensive activities and revealed affinity for α1- and α2-adrenoceptors. These effects may be related to their α-adrenolytic properties. We assessed their antidepressant-like effect in the forced swimming tes...

The quartic gauge boson couplings that identify the strengths of self-interactions are exactly determined by non-Abelian nature Standard Model. examination these at $ep$ collisions with high center-of-mass energy and integrated luminosity provides an important opportunity to test validity Model existence new physics beyond can contribute directly multi-boson production colliders. Therefore, we ...

neonate ruminants possess little cell-wall and starch degrading enzyme activity. importantly, early establishment of fibrolytic, amylolytic, and proteolytic capacities is influential for the early expansion of the reticulorumen epithelia. such an early development in reticulorumen fermentation will enable a timely hepatic adaptation to volatile fatty acids assimilation. the early nutrient relea...

The role of erythropoietin (EP) in polycythemia vera (PV) is controversial, with some experiments suggesting that erythroid progenitors in PV are exquisitely sensitive to EP and EP dependent, and others suggesting that PV progenitors are EP independent. We have examined the characteristics of the EP receptor (EP-R) on erythroid colony-forming cells (ECFC) from patients with PV. In contrast to n...

A thin film of epinephrine (EP) was electrochemically deposited on the surface of glassy carbon electrode previously activated in NaHCO3 solution. The cyclic voltammograms of the modified electrode indicate that the surface confined EP are strongly dependent on the solution pH, as expected for quinone/hydroquinone functionalities. The EP-modified glassy carbon electrode exhibited...