Rosuvastatin is a lipid lowering agent, which has low solubility and low bioavailability of 20% with oral administration. Therefore the present study was undertaken to improve solubility and bioavailability of Rosuvastatin by formulating it into Nano structured lipid carriers (NLCs) by using stearic acid and Compritol ATO 888 as solid-lipid, Oleic acid as liquid-lipid and Poloxamer 188 as a sur...

background: sustained release delivery system can reduce the dosage frequency and maintain the therapeutic level of drugs for a longer time. biodegradable, biocompatible and thermosensitive chitosan-beta-glycerophosphate (c-gp) solutions can solidify at body temperature and maintain their physical integrity for a longer duration. objectives: to develop a novel delivery system based on the integ...

objective(s): over the past two decades, considerable interest has been focused on utilizing biocompatible magnetic nanoparticles (mnps) for biomedical applications. in this study, production of human serum albumin (hsa) nanoparticles using desolvation technique that were simultaneous loaded with high amounts of superparamagnetic iron oxide nanoparticles (spions) and 5-flourouracil (5-fu) was i...

low molecular weight heparin-modified isoliquiritigenin-loaded solid lipid nanoparticle (lmwh-isl-sln) was developed for injective application. the morphological observation, particle diameter and zeta potential of lmwh-isl-sln were characterized using transmission electron microscopy (tem) and a malvern zetasizer. its entrapment efficiency (ee) and drug loading (dl) were determined by ultracen...

chemotherapy research highly prioritizes overcoming the multidrug resistance (mdr) in human tumors. liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. liposomes were prepared using different active loading techniques. the influence of diff...

thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. to increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. hydroxy propyl methyl cellulose (hpmc) and ethyl cellulose (ec) were used as the matrix polymer here. mixtures of thymol with eight ...

The major challenge to treat Parkinson’s disease (PD) is penetration of target molecule into the brain to improve the efficacy of drugs. To achieve better brain penetration and targeted delivery, 1,9-Pyrazoloanthrone (1,9-P) loaded liposomes were developed by solvent injection technique using ultrasonication and evaluated for particle size, morphology, entrapment efficiency, FT-IR, and in-vitro...

Cationic polymeric nanoparticles have great potential for developing drug delivery systemswith limited side effects for tumor medication. The goal of this research is investigation ofcationic dextran-spermine polymer (DS) efficacy for improvement of hydrophilic drug deliveryto negatively charged cancerous cells. Capecitabine (as a hydrophilic antineoplastic drug) wasloaded into the magnetic dex...

Objective(s) The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. Materials and Methods Microspheres were prepared by water-in-oil-in-oil (W/O1/O2) emulsion-solvent diffusion (ESD). A mixed solvent system consisting of acetonitrile and dichloromet...

The present study investigated the characteristics of diclofenac diethylammonium-containing NLC as function ratio glyceryl monostearate (GMS) and caprylic acid (mygliol 80) 65:35; 75:25 85:15. There were three formulas composition each formula diethylammonium 1.16%; with (65:35; 85:15); Tween 80 5%; phosphate buffer pH 6.0 ± 0.1 dispersion medium. result showed that had different characteristic...