Deep Mutational Scanning is a robust method for massive scale assessment of genotypic variants and is being applied to wide domains of research. dms2dfe (Deep Mutational Scanning to Distribution of Fitness Effects) is a comprehensive computational workflow designed to streamline analysis of such data on the basis of evolutionary principles. dms2dfe assists in contextualizing data from Deep Muta...

Sources of blood glucose can be determined after oral ingestion of (2)H(2)O followed by isolation of plasma glucose and measurement of the relative (2)H enrichments in select positions within the glucose molecule. Typically, (2)H enrichments are obtained by mass spectrometry but (2)H NMR offers an alternative. Here it is demonstrated that the entire analysis may be automated by Bayesian analysi...

Significant selective enrichments of mutants defective in catabolic pathways can be achieved by exposure of pseudomonad cells to halogenated analogs of growth substrates. Between 3 and 95% of viable clones rescued from such enrichments have been defective in specific catabolic pathways. This has been demonstrated for eight different catabolic pathways for aromatic compounds in pseudomonads, in ...

We report Solar Orbiter observations of six recurrent solar energetic particle injections in 2022 March 3−6 at ∼0.5 au. All but one were associated with jets emanating from a plage near large sunspot active region 12 957. saw high 3 He and Fe enrichments minor no or lower enrichments. Furthermore, the event highest enrichment showed more compact configuration underlying photospheric magnetic fi...

The Miño River is a good example of bedrock rivers, where sediment geochemistry scarcely studied. Its urban reach when passing through the city Ourense gathers some characteristics that provide interest to its sediments, like scarcity fine sediments accumulation and impact several human activities. Sediments trapped by potholes other rock cavities were considered. In order evaluate society-natu...