introduction: secondary radiation such as photoelectrons, auger electrons and characteristic radiations cause a local boost in dose for a tumor when irradiated with an external x-ray beam after being loaded with elements capable of activating the tumor, e.g.; i and gd. materials and methods:  in this investigation, the mcnpx code was used for simulation and calculation of dose enhancement facto...

We evaluated the immunogenicity of virus-like replicon particles (VRP) derived from an attenuated strain of the alphavirus Venezuelan equine encephalitis virus, encoding two pre-erythrocytic Plasmodium yoelii antigens, in mice. Three immunizing doses were superior to two, and the subcutaneous route was comparable to intramuscular and more immunogenic than intradermal, at doses between 5x10 5 5x...

Dengue is the most prevalent mosquito-borne viral disease worldwide. Yet, there are no vaccines or specific antivirals available to prevent or treat the disease. Several dengue vaccines are currently in clinical or preclinical stages. The most advanced vaccine is the chimeric tetravalent CYD-TDV vaccine of Sanofi Pasteur. This vaccine has recently cleared Phase III, and efficacy results have be...

We have previously described protective effects of oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) on pulmonary endothelial cell (EC) barrier function and demonstrated the critical role of cyclopentenone-containing modifications of arachidonoyl moiety in OxPAPC protective effects. In this study we used oxidized phosphocholine (OxPAPC), phosphoserine (OxPAPS), and glycer...

background imaging plays a critical role not only in the detection, but also in the characterization of lung masses as benign or malignant. objectives to determine the diagnostic accuracy of dynamic magnetic resonance imaging (mri) in the differential diagnosis of benign and malignant lung masses. patients and methods ninety-four masses were included in this prospective study. five dynamic seri...

the effects of substituents on the symmetry and the nature of halogen bonds in [n∙∙∙x∙∙∙n]+-type systems are presented for the yc5h4n∙∙∙x∙∙∙nc5h5 (y = no2, cn, h, ch3, och3, oh, nh2, x = cl, br, i) complexes. some structural parameters, energy data and electronic properties were explored with the density functional theory (dft) calculations. in addition, electrostatic potentials were used in es...

objective(s):painful diabetic neuropathy is associated with hyperexcitability and hyperactivity of spinal cord neurons. however, its underlying pathophysiological mechanisms have not been fully clarified. induction of excitatory/inhibitory neurotransmission imbalance at the spinal cord seems to account for the abnormal neuronal activity in diabetes. protective properties of neurosteroids have b...