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Cell therapy is a promising approach to generate an enteric nervous system (ENS) and treat enteric neuropathies. However, for translation to the clinic, it is highly likely that enteric neural progenitors will require manipulation prior to transplantation to enhance their ability to migrate and generate an ENS. In this study, we examine the effects of exposure to several factors on the ability ...
Zebrafish lacking functional sox10 have defects in non-ectomesenchymal neural crest derivatives including the enteric nervous system (ENS) and as such provide an animal model for human Waardenburg Syndrome IV. Here, we characterize zebrafish phox2b as a functionally conserved marker of the developing ENS. We show that morpholino-mediated knockdown of Phox2b generates fish modeling Hirschsprung ...
In Parkinson's disease (PD) patients, the associated pathology follows a characteristic pattern involving inter alia the enteric nervous system (ENS) (1,2), the olfactory bulb (OB), the dorsal motor nucleus of the vagus (DMV)(3), the intermediolateral nucleus of the spinal cord (4) and the substantia nigra, providing the basis for the neuropathological staging of the disease(4,5). The ENS and t...
The capacity to identify and isolate lineage-specific progenitor cells from developing and mature tissues would enable the development of cell replacement therapies for disease treatment. The enteric nervous system (ENS) regulates important gut functions, including controlling peristaltic muscular contractions, and consists of interconnected ganglia containing neurons and glial cells. Hirschspr...
Self-replication is a remarkable phenomenon in nature that has fascinated scientists for decades. In a self-replicating system, the original units are attracted to a template, which induce their binding. In equilibrium, the energy required to disassemble the newly assembled copy from the mother template is supplied by thermal energy. The possibility of optimizing self-replication was explored b...
The enteric nervous system (ENS) is a complex network of neurons and glia within the gut wall which originate from neural crest cells. Self-renewing, multipotential ENS progenitors have been isolated from the gut of foetal as well as adult rodents, however, the identity of the ENS progenitor and the regulation of its neurogenic potential invivo, are currently unknown. Sox10 is an HMG-containing...
Enteric glia play an important neuroprotective role in the enteric nervous system (ENS) by producing neuroprotective compounds such as the antioxidant reduced glutathione (GSH). The specific cellular pathways that regulate glial production of GSH and how these pathways are altered during, or contribute to, neuroinflammation in situ and in vivo are not fully understood. We investigated this issu...
In the context of global/goal-oriented error estimation applied to computational mechanics, the need to obtain reliable and guaranteed bounds on the discretization error has motivated the use of residual error estimators. These estimators require the construction of admissible stress fields verifying the equilibrium exactly. This article focuses on a recent method, based on a flux-equilibration...
شبکه های توزیع بخش حیاتی سیستم تامین انرژی الکتریکی می باشد.آرایش شبکه های توزیع معمولا بصورت شعاعی می باشد و با همین آرایش نیز بهره برداری می شود. شبکه های توزیع دارای چندین خطوط مانور بوده که منجر به آرایش های مختلفی در بازآرایی آن خواهد شد. فرآیند بازآرایی می تواند شامل قطع برخی از خطوط اصلی و بستن برخی از خطوط مانور به منظور دستیابی به یک آرایش جدید باشد. در سال های اخیر به منظور بهبود قاب...
میزان هدررفت خاک در مراتع به عنوان یک شاخص کمی برای حفاظت و سلامتی مرتع درنظر گرفته می-شود. با توجه به اهمیت فرسایش خاک در مراتع یک مدل پیش بینی فرسایش در مراتع که به طور ویژه نقش پوشش را در نظر بگیرد مورد نیاز است. لذا تحقیق حاضر به منظور بررسی کارایی مدل rhem در برآورد میزان فرسایش اراضی مرتعی حوزه آبخیز زاینده رود، با بررسی مشخصات 70 رویداد بارندگی در 5 پلات به همراه اندازه گیری میزان رسوب و...
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