Ibogaine is an indole alkaloid present in the root of the plant Tabernanthe iboga. It is known to attenuate abstinence syndrome in animal models of drug addiction. Since the anti-addiction effect lasts longer than the presence of ibogaine in the body, some profound metabolic changes are expected. The aim of this study was to investigate the effect of ibogaine on protein expression in rat brains...

Among the microflora of the gingival sulcus are members of the genus Capnocytophaga which have been implicated as possible etiological agents of juvenile periodontitis and systemic infectious diseases. In this study, the pathway used by C. ochracea strain 25 for generating energy from glucose was investigated. When grown in a complex medium supplemented with glucose and NaHCO(3), the major end ...

Cystic fibrosis (CF) remains a major cause of refractory malnutrition in clinical practice. It is clinically and genetically a heterogeneous disorder, and energy metabolism, as with other manifestations of the disease, is subject to wide variability. Differences in metabolic needs are related to the specific CF genotype, and are the result of a complex interaction of physiological, environmenta...

In early studies on energy metabolism of tumor cells, it was proposed that the enhanced glycolysis was induced by a decreased oxidative phosphorylation. Since then it has been indiscriminately applied to all types of tumor cells that the ATP supply is mainly or only provided by glycolysis, without an appropriate experimental evaluation. In this review, the different genetic and biochemical mech...

Cancer is a disease characterized by uncontrolled growth. Metabolic demands to sustain rapid proliferation must be compelling since aerobic glycolysis is the first as well as the most commonly shared characteristic of cancer. During the last decade, the significance of metabolic reprogramming of cancer has been at the center of attention. Nonetheless, despite all the knowledge gained on cancer ...

In a discussion of energy metabolism in the elderly, we ought to try to be modestly précise about what exactly is meant by the "elderly." There is enough individual variation among a group of elderly people who are ail of the same âge to create difficult problems and if we lump together the whole âge range from 65 years onward (as is frequently done in tables of energy and nutrient requirements...